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A Mn(I)\u2010catalyzed method for synthesizing 1,2,3,4\u2010tetrahydroquinoxalines via the direct reaction of <jats:italic>o<\/jats:italic>\u2010phenylenediamine with diols under mild conditions (80\u00a0\u00b0C) is described. The catalyst, [Mn(bis\u20101,2,3\u2010triazolylidene)(CO)<jats:sub>3<\/jats:sub>Br], which features a bidentate triazolylidene ligand, is air\u2010stable, easy to prepare, and exhibits broad activity across a wide range of substrates. Additionally, this Mn\u2010triazolylidene complex efficiently catalyzes the N,N\u00b4\u2010dialkylation of a variety of <jats:italic>o<\/jats:italic>\u2010 and <jats:italic>p<\/jats:italic>\u2010phenylenediamines with a range of primary alcohols, such as benzyl alcohols, furfuryl alcohol, and 3\u2010pyridine methanol, using catalytic amount of base and mild conditions (100\u00a0\u00b0C, 6\u00a0h). Notably, this method enables the derivatization of the important drug molecule Dapson, showcasing its practical utility. The catalyst also allows both selective monoalkylation and dialkylation of a broad range\u00a0of aniline derivatives\u00a0using aliphatic diols as alkylating agents. This method provides the corresponding alkylated amines in excellentyields, typically between 81% to 99%, thereby underscoring its efficiency. The straighforward nature of the method, together with the use of readily available manganese catalyst, makes this strategy particularly appealing and suggests significant potential for wider use in the synthesis of parmaceutically relevant molecules.<\/jats:p>","DOI":"10.1002\/cctc.202500113","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T08:04:57Z","timestamp":1744099497000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Manganese\u2010Triazolylidene Catalysis for The Synthesis of 1,2,3,4\u2010Tetrahydroquinoxalines and Selective Alkylation of Diamines and Anilines with Alcohols and Diols"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7465-0346","authenticated-orcid":false,"given":"Beatriz","family":"Garcia","sequence":"first","affiliation":[{"name":"ITQB NOVA, Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier Universidade Nova de Lisboa  Avenida da Rep\u00fablica Oeiras 2780\u2010157 Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8165-3326","authenticated-orcid":false,"given":"Sofia","family":"Fri\u00e3es","sequence":"additional","affiliation":[{"name":"ITQB NOVA, Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier Universidade Nova de Lisboa  Avenida da Rep\u00fablica Oeiras 2780\u2010157 Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6319-5277","authenticated-orcid":false,"given":"Daniel","family":"Raydan","sequence":"additional","affiliation":[{"name":"ITQB NOVA, Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier Universidade Nova de Lisboa  Avenida da Rep\u00fablica Oeiras 2780\u2010157 Portugal"},{"name":"LAQV\u2010REQUIMTE, Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia Universidade Nova de Lisboa  Campus de Caparica Caparica 2829\u2010516 Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6712-752X","authenticated-orcid":false,"given":"M. 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