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The cytotoxicity of Na[COSAN] was also tested towards one normal cell line, the V79 fibroblasts, in order to ascertain the noncytotoxic profile of the compound. As the cell's nucleus contains DNA, the interaction between [COSAN]<jats:sup>\u2212<\/jats:sup> and double\u2010stranded calf thymus DNA (CT\u2010<jats:italic>ds<\/jats:italic>DNA) has been investigated. There is a strong interaction between both molecules forming a nanohybrid CT\u2010<jats:italic>ds<\/jats:italic>DNA\u2010[COSAN] biomaterial, which was fully characterized. Moreover, Na[COSAN] shows characteristic redox peaks ascribed to the oxidation\/reduction of Co<jats:sup>3+\/2+<\/jats:sup> at a formal potential of \u22121.444\u2005V and it can be accumulated at a surface\u2010immobilized DNA layer of glassy carbon electrodes. The equilibrium surface\u2010binding constants (<jats:italic>K<\/jats:italic><jats:sub>ox<\/jats:sub>\/<jats:italic>K<\/jats:italic><jats:sub>red<\/jats:sub>), which confirm that [COSAN]<jats:sup>\u2212<\/jats:sup> interacts with DNA by an intercalative or electrostatic mode, depending on the ionic strength of the solution, were estimated. In addition, high binding affinity of Na[COSAN] to proteins was observed by <jats:sup>11<\/jats:sup>B{<jats:sup>1<\/jats:sup>H}\u2005NMR and confirmed in vivo. Finally, biodistribution studies of [COSAN]<jats:sup>\u2212<\/jats:sup> in normal mice were run. After administration, Na[COSAN] was distributed into many organs but mainly accumulated in the reticuloendothelial system (RES), including liver and spleen. After 1\u2005h, the formation of aggregates by plasma protein interaction plays a role in the biodistribution profile; the aggregates accumulate mostly in the lungs. Na[COSAN], which displays low toxicity and high uptake by relevant cancer cells accumulating boron within the nucleus, could act as a suitable compound for further developments as boron neutron capture therapy (BNCT) agents.<\/jats:p>","DOI":"10.1002\/chem.201803178","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T11:45:55Z","timestamp":1537184755000},"page":"17239-17254","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":116,"title":["Metallacarboranes on the Road to Anticancer Therapies: Cellular Uptake, DNA Interaction, and Biological Evaluation of Cobaltabisdicarbollide [COSAN]<sup>\u2212<\/sup>"],"prefix":"10.1002","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1051-127X","authenticated-orcid":false,"given":"Isabel","family":"Fuentes","sequence":"first","affiliation":[{"name":"Institut de Ci\u00e8ncia de Materials de Barcelona (ICMAB-CSIC) Campus UAB  08193 Bellaterra Barcelona Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7634-5844","authenticated-orcid":false,"given":"Tania","family":"Garc\u00eda\u2010Mendiola","sequence":"additional","affiliation":[{"name":"Instituto Madrile\u00f1o de Estudios Avanzados (IMDEA) Nanociencia  28049 Madrid Spain"},{"name":"Departamento Qu\u00edmica Anal\u00edtica<i>y<\/i>An\u00e1lisis Instrumental Universidad Aut\u00f3noma de Madrid  Spain"},{"name":"Institute for Advanced Research in Chemical Sciences (IAdChem) Universidad Aut\u00f3noma de Madrid  28049 Madrid Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8563-1658","authenticated-orcid":false,"given":"Shinichi","family":"Sato","sequence":"additional","affiliation":[{"name":"Laboratory for Chemistry and Life Science Institute of Innovative Research Tokyo Institute of Technology  4259\u2005Nagatsuta-cho, Midori-ku Yokohama 226-8503 Japan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6714-3669","authenticated-orcid":false,"given":"Marcos","family":"Pita","sequence":"additional","affiliation":[{"name":"Instituto de Catalisis (CSIC) Campus Universidad Aut\u00f3noma  28049 Madrid Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4511-2984","authenticated-orcid":false,"given":"Hiroyuki","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Laboratory for Chemistry and Life Science Institute of Innovative Research Tokyo Institute of Technology  4259\u2005Nagatsuta-cho, Midori-ku Yokohama 226-8503 Japan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8432-9652","authenticated-orcid":false,"given":"Encarnaci\u00f3n","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"Instituto Madrile\u00f1o de Estudios Avanzados (IMDEA) Nanociencia  28049 Madrid Spain"},{"name":"Departamento Qu\u00edmica Anal\u00edtica<i>y<\/i>An\u00e1lisis Instrumental Universidad Aut\u00f3noma de Madrid  Spain"},{"name":"Institute for Advanced Research in Chemical Sciences (IAdChem) Universidad Aut\u00f3noma de Madrid  28049 Madrid Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3010-2417","authenticated-orcid":false,"given":"Francesc","family":"Teixidor","sequence":"additional","affiliation":[{"name":"Institut de Ci\u00e8ncia de Materials de Barcelona (ICMAB-CSIC) Campus UAB  08193 Bellaterra Barcelona Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8440-5299","authenticated-orcid":false,"given":"Fernanda","family":"Marques","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias e Tecnologias Nucleares (C<sup>2<\/sup>TN) Instituto Superior T\u00e9cnico Universidade de Lisboa  Estrada Nacional\u200510 (km 139.7) 2695-066 Bobadela, LRS Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5000-0277","authenticated-orcid":false,"given":"Clara","family":"Vi\u00f1as","sequence":"additional","affiliation":[{"name":"Institut de Ci\u00e8ncia de Materials de Barcelona (ICMAB-CSIC) Campus UAB  08193 Bellaterra Barcelona Spain"}]}],"member":"311","published-online":{"date-parts":[[2018,11,9]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_7_2_1","unstructured":"\u00a0"},{"key":"e_1_2_7_3_2","first-page":"183","volume":"10","author":"Biemar F.","year":"2013","journal-title":"Cancer Biol. 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