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The presence of a bromine atom suggests that it is also reactive towards low\u2010energy electrons, which are produced in large quantities during tumour radiation therapy. Detailed knowledge of the interaction of 3BP with secondary electrons is a prerequisite to gain a complete picture of the effects of 3BP in different forms of cancer therapy. Herein, dissociative electron attachment (DEA) to 3BP in the gas phase has been studied both experimentally by using a crossed\u2010beam setup and theoretically through scattering and quantum chemical calculations. These results are complemented by a vacuum ultraviolet absorption spectrum. The main fragmentation channel is the formation of Br<jats:sup>\u2212<\/jats:sup> close to 0\u2005eV and within several resonant features at 1.9 and 3\u20138\u2005eV. At low electron energies, Br<jats:sup>\u2212<\/jats:sup> formation proceeds through \u03c3* and \u03c0* shape resonances, and at higher energies through core\u2010excited resonances. It is found that the electron\u2010capture cross\u2010section is clearly increased compared with that of non\u2010brominated pyruvic acid, but, at the same time, fragmentation reactions through DEA are significantly altered as well. The 3BP transient negative ion is subject to a lower number of fragmentation reactions than those of pyruvic acid, which indicates that 3BP could indeed act by modifying the electron\u2010transport chains within oxidative phosphorylation. It could also act as a radio\u2010sensitiser.<\/jats:p>","DOI":"10.1002\/chem.201806132","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T06:20:29Z","timestamp":1549002029000},"page":"5498-5506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Electron\u2010Induced Reactions in 3\u2010Bromopyruvic Acid"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2182-2965","authenticated-orcid":false,"given":"Filipe","family":"Ferreira\u2005da\u2005Silva","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Colis\u00f5es At\u00f3micas e Moleculares, CEFITEC Departamento de F\u00edsica Faculdade de Ci\u00eancias e Tecnologia Universidade NOVA de Lisboa  2829-516 Caparica Portugal"}]},{"given":"M\u00e1rcio T.","family":"do\u2005N.\u2005Varella","sequence":"additional","affiliation":[{"name":"Instituto de F\u00edsica Universidade de S\u00e3o Paulo  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