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Furthermore, the thermodynamic properties of these complexes in solution remain difficult to establish. The challenge is compounded when considering that radiolabeling of compounds for translation to clinical trials requires fast complexation. Thus, the coordination of Pd(II) and <jats:sup>103\/109<\/jats:sup>Pd\u2010nuclides is a huge challenge in terms of molecular design and physicochemical characterization. Herein, we report a comprehensive study highlighting <jats:bold>TE1PA<\/jats:bold>, a monopicolinate cyclam \u2013 already established in nuclear imaging with <jats:sup>64<\/jats:sup>Cu\u2010PET (positron emission tomography) imaging tracers \u2013 as a highly relevant chelator for natural Pd and subsequently <jats:sup>109<\/jats:sup>Pd\u2010nuclide. The structural, thermodynamic, kinetic and radiolabeling studies of Pd(II) with <jats:bold>TE1PA<\/jats:bold>, as well as the comparison of this complex with three structurally related derivatives, support palladium\u2010<jats:bold>TE1PA<\/jats:bold> radiopharmaceuticals as leading candidates for targeted nuclear medicine.<\/jats:p>","DOI":"10.1002\/chem.202200942","type":"journal-article","created":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T05:59:24Z","timestamp":1652421564000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Relevance of Palladium to Radiopharmaceutical Development Considering Enhanced Coordination Properties of TE1PA"],"prefix":"10.1002","volume":"28","author":[{"given":"Julie","family":"Pineau","sequence":"first","affiliation":[{"name":"Univ Brest, UMR CNRS 6521 CEMCA  6 avenue Victor le Gorgeu 29238 Brest France) E-mail: s"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9729-330X","authenticated-orcid":false,"given":"Lu\u00eds M. 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