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Towards this goal, we have developed isostructural <jats:sup>99m<\/jats:sup>Tc(I) and Re(I) tricarbonyl complexes anchored by a pyrazolyl\u2010diamine (Pz) chelator carrying a pendant pyridostatin (PDS) fragment as the G4\u2010binding motif. The interaction of the PDF\u2010Pz\u2010Re (<jats:bold>8<\/jats:bold>) complex with different G4\u2010forming oligonucleotides was studied by circular dichroism, fluorescence spectroscopy and FRET\u2010melting assays. The results showed that the Re complex retained the ability to bind and stabilize G4\u2010structures from different DNA or RNA sequences, namely those present on the SRC proto\u2010oncogene and telomeric RNA (TERRA sequence). PDF\u2010Pz\u2010Re (<jats:bold>8<\/jats:bold>) showed low to moderate cytotoxicity in PC3 and MCF\u20107 cancer cell lines, as typically observed for G4\u2010binders. 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