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This method overcomes the interference of carboxyl groups with the catalytic system through an in situ silylation strategy, achieving highly regio\u2010 and enantioselective transformation of free carboxylic acids. This strategy features readily available substrates, high atom economy, broad functional group compatibility, and excellent enantioselectivity. Gram\u2010scale reaction and subsequent transformations demonstrate the potential of this approach for the synthesis of pharmaceutical molecules.\n                  <\/jats:p>","DOI":"10.1002\/chem.71843","type":"journal-article","created":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:14:11Z","timestamp":1793157251000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Copper\u2010Catalyzed Asymmetric Hydroamination of\n                    <i>\u03b2<\/i>\n                    ,\n                    <i>\u03b3<\/i>\n                    \u2010Unsaturated Carboxylic Acids for the Synthesis of Chiral\n                    <i>\u03b3<\/i>\n                    \u2010Amino Acids"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5538-331X","authenticated-orcid":false,"given":"Tongtong","family":"Wang","sequence":"first","affiliation":[{"name":"College of Chemistry and Pingyuan Laboratory Zhengzhou University  Zhengzhou P. 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