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The proposed overview of reviews aims to: (1) aggregate and systematize findings from multiple overviews of reviews, and offer a broader understanding of the factors, both facilitators and barriers related to PrEP awareness, uptake, and adherence among MSM; and (2) understand if there are gaps in the literature on potential facilitators and barriers that need greater analysis. Hence, the purpose of this overview of reviews aligns with Sustainable Development Goal 3 of the 2030 Agenda for Sustainable Development, particularly with SDG 3.3, that is, end the epidemics of AIDS and other communicable diseases.<\/jats:p>","DOI":"10.1002\/cl2.70047","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T06:52:33Z","timestamp":1751871153000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["PROTOCOL: PrEP (Non)Adherence Among Men Who Have Sex With Men: An Overview of Reviews: A Systematic Review"],"prefix":"10.1177","volume":"21","author":[{"given":"Guilherme G.","family":"Pinheiro","sequence":"first","affiliation":[{"name":"CIS\u2010Iscte Lisbon Portugal"}]},{"given":"Carla","family":"Moleiro","sequence":"additional","affiliation":[{"name":"CIS\u2010Iscte Lisbon Portugal"}]},{"given":"David L.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"CIS\u2010Iscte Lisbon Portugal"}]}],"member":"179","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.46658\/JBIMES-24-08"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/xeb.0000000000000055"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10508-018-1260-1"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1521\/aeap.2020.32.5.416"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2021.0236"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.35"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.naj.0000997216.21988.19"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/17437199.2019.1641424"},{"key":"e_1_2_10_10_1","unstructured":"Gaetani M. 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