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Biological studies revealed their negligible dark cytotoxicity, yet significant photodynamic effect against A549 (human lung adenocarcinoma), MCF7 (human breast carcinoma) and SK\u2010MEL\u2010188 (human melanoma) cell lines upon red light irradiation (cutoff<\/jats:italic> \u03bb<jats:italic>&lt;600\u2005nm) at low light doses. Time\u2010dependent cellular accumulation of the chlorinated sulfonated chlorin reached a plateau at 2\u2005h, as previously observed for the related porphyrin. However, the optimal incubation time for the bacteriochlorin derivative was significantly longer (12\u2005h). The spectroscopic, photophysical, and biological properties of the compounds are discussed in relevance to their PDT activity, leading to the conclusion that the bacteriochlorin derivative is a promising candidate for future in\u2005vivo experiments.<\/jats:italic><\/jats:p>","DOI":"10.1002\/cmdc.201000223","type":"journal-article","created":{"date-parts":[[2010,8,16]],"date-time":"2010-08-16T19:13:58Z","timestamp":1281986038000},"page":"1770-1780","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":103,"title":["New Halogenated Water\u2010Soluble Chlorin and Bacteriochlorin as Photostable PDT Sensitizers: Synthesis, Spectroscopy, Photophysics, and in\u2005vitro Photosensitizing Efficacy"],"prefix":"10.1002","volume":"5","author":[{"given":"Janusz M.","family":"D\u0105browski","sequence":"first","affiliation":[]},{"given":"Luis G.","family":"Arnaut","sequence":"additional","affiliation":[]},{"given":"Mariette M.","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Carlos J. 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