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This paper reports cytotoxicity, phototoxicity, in vitro cellular uptake, and in vivo biodistribution and PDT efficacy of a synthetic chlorin derivative (TCPCSO<jats:sub>3<\/jats:sub>H) towards Cloudman melanoma cells (S91). No cytotoxic effects were observed in vitro at concentrations up to 20\u2005\u03bc<jats:sc>m,<\/jats:sc> and no toxicity was observed in vivo in DBA mice with doses up to 2\u2005mg\u2009kg<jats:sup>\u22121<\/jats:sup>. Pharmacokinetics and biodistribution of TCPCSO<jats:sub>3<\/jats:sub>H were evaluated in vivo in DBA mice bearing S91 tumors. TCPCSO<jats:sub>3<\/jats:sub>H demonstrated preferential accumulation in S91 mouse melanoma, with tumor\u2010to\u2010normal tissue ratios of 5 and 11 for muscle and skin, respectively, 24\u2005h after intravenous injection of 2\u2005mg\u2009kg<jats:sup>\u22121<\/jats:sup>. Photodynamic therapy performed under these conditions with 70\u2005mW\u2009cm<jats:sup>\u22122<\/jats:sup> diode laser irradiation at 655\u2005nm for 25\u2005min (total light dose=105\u2005J\u2009cm<jats:sup>\u22122<\/jats:sup>) resulted in scab formation, followed by temporary or permanent (&gt;60 days) tumor remission. According to the Kaplan\u2013Meier analysis, the median survival time of the control group was 9\u2005days, whereas that of the treated group was 38\u2005days.<\/jats:p>","DOI":"10.1002\/cmdc.201100186","type":"journal-article","created":{"date-parts":[[2011,7,5]],"date-time":"2011-07-05T11:59:58Z","timestamp":1309867198000},"page":"1715-1726","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Tissue Uptake Study and Photodynamic Therapy of Melanoma\u2010Bearing Mice with a Nontoxic, Effective Chlorin"],"prefix":"10.1002","volume":"6","author":[{"given":"Janusz M.","family":"D\u0105browski","sequence":"first","affiliation":[]},{"given":"Martyna","family":"Krzykawska","sequence":"additional","affiliation":[]},{"given":"Luis G.","family":"Arnaut","sequence":"additional","affiliation":[]},{"given":"Mariette M.","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Carlos J. 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