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With the aim of finding new MAO\u2010B\u2010selective inhibitors, we report the synthesis, in\u2005vitro evaluation, and docking simulation of a new series of 3\u2010arylcoumarins variously substituted at the 8\u2010position. Most of the studied compounds show high affinity and selectivity for the hMAO\u2010B isoform, with IC<jats:sub>50<\/jats:sub> values in the low micro\u2010 to nanomolar range. Some of them have greater hMAO\u2010B inhibitory activity and selectivity than the reference compound, selegiline. Compounds <jats:bold>7<\/jats:bold> and <jats:bold>8<\/jats:bold> are the most active of this series, with compound <jats:bold>8<\/jats:bold> being fivefold more potent against MAO\u2010B and severalfold more selective than selegiline. Docking experiments were carried out with hMAO\u2010B crystal structures, providing new information about the enzyme\u2013inhibitor interaction and the potential therapeutic application of the new 8\u2010substituted 3\u2010arylcoumarins.<\/jats:p>","DOI":"10.1002\/cmdc.201100538","type":"journal-article","created":{"date-parts":[[2012,1,27]],"date-time":"2012-01-27T17:24:46Z","timestamp":1327685086000},"page":"464-470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["8\u2010Substituted 3\u2010Arylcoumarins as Potent and Selective MAO\u2010B Inhibitors: Synthesis, Pharmacological Evaluation, and Docking Studies"],"prefix":"10.1002","volume":"7","author":[{"given":"Dolores","family":"Vi\u00f1a","sequence":"first","affiliation":[]},{"given":"Maria J.","family":"Matos","sequence":"additional","affiliation":[]},{"given":"Giulio","family":"Ferino","sequence":"additional","affiliation":[]},{"given":"Enzo","family":"Cadoni","sequence":"additional","affiliation":[]},{"given":"Reyes","family":"Laguna","sequence":"additional","affiliation":[]},{"given":"Fernanda","family":"Borges","sequence":"additional","affiliation":[]},{"given":"Eugenio","family":"Uriarte","sequence":"additional","affiliation":[]},{"given":"Lourdes","family":"Santana","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2012,1,27]]},"reference":[{"key":"e_1_2_7_1_2","first-page":"197","volume-title":"Monoamine Oxidase: Basic and Clinical Frontiers in Excerpta Medica","author":"Dostert P.","year":"1982"},{"key":"e_1_2_7_2_2","first-page":"437","volume-title":"Chemistry and Biochemistry of Flavoenzymes, Vol.\u20052","author":"Singer T. 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