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As it is known that CB<jats:sub>1<\/jats:sub> receptors are also located peripherally, there is growing interest in targeting cannabinoid receptors located outside the brain. A library of chromenopyrazoles designed analogously to the classical cannabinoid cannabinol were synthesized, characterized, and tested for cannabinoid activity. Radioligand binding assays were used to determine their affinities at CB<jats:sub>1<\/jats:sub> and CB<jats:sub>2<\/jats:sub> receptors. Structural features required for CB<jats:sub>1<\/jats:sub>\/CB<jats:sub>2<\/jats:sub> affinity and selectivity were explored by molecular modeling. Some compounds in the chromenopyrazole series were observed to be selective CB<jats:sub>1<\/jats:sub> ligands. These modeling studies suggest that full CB<jats:sub>1<\/jats:sub> selectivity over CB<jats:sub>2<\/jats:sub> can be explained by the presence of a pyrazole ring in the structure. The functional activities of selected chromenopyrazoles were evaluated in isolated tissues. In\u2005vivo behavioral tests were then carried out on the most effective CB<jats:sub>1<\/jats:sub> cannabinoid agonist, <jats:bold>13\u2009a<\/jats:bold>. Chromenopyrazole <jats:bold>13\u2009a<\/jats:bold> did not induce modifications in any of the tested parameters on the mouse cannabinoid tetrad, thus discounting CNS\u2010mediated effects. This lack of agonistic activity in the CNS suggests that this compound does not readily cross the blood\u2013brain barrier. Moreover, <jats:bold>13\u2009a<\/jats:bold> can induce antinociception in a rat peripheral model of orofacial pain. Taking into account the negative results obtained with the hot\u2010plate test, the antinociception induced by <jats:bold>13\u2009a<\/jats:bold> in the orofacial test could be mediated through peripheral mechanisms.<\/jats:p>","DOI":"10.1002\/cmdc.201100568","type":"journal-article","created":{"date-parts":[[2012,2,2]],"date-time":"2012-02-02T09:49:54Z","timestamp":1328176194000},"page":"452-463","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Chromenopyrazoles: Non\u2010psychoactive and Selective CB<sub>1<\/sub> Cannabinoid Agonists with Peripheral Antinociceptive Properties"],"prefix":"10.1002","volume":"7","author":[{"given":"Jose","family":"Cumella","sequence":"first","affiliation":[]},{"given":"Laura","family":"Hern\u00e1ndez\u2010Folgado","sequence":"additional","affiliation":[]},{"given":"Rocio","family":"Gir\u00f3n","sequence":"additional","affiliation":[]},{"given":"Eva","family":"S\u00e1nchez","sequence":"additional","affiliation":[]},{"given":"Paula","family":"Morales","sequence":"additional","affiliation":[]},{"given":"Dow P.","family":"Hurst","sequence":"additional","affiliation":[]},{"given":"Maria","family":"G\u00f3mez\u2010Ca\u00f1as","sequence":"additional","affiliation":[]},{"given":"Maria","family":"G\u00f3mez\u2010Ruiz","sequence":"additional","affiliation":[]},{"given":"Diana C. 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