{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T23:13:32Z","timestamp":1768000412755,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,27]],"date-time":"2013-12-27T00:00:00Z","timestamp":1388102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intravenous (i.v.) formulations with various amounts of organic solvents [PEG<jats:sub>400<\/jats:sub>, propylene glycol (PG), cremophor\u2005EL (CrEL)] were used to deliver a fluorinated sulfonamide bacteriochlorin to mice, rats, and minipigs. Biodistribution studies in mice showed that a low\u2010content CrEL formulation combines high bioavailability with high tumor\u2010to\u2010muscle and tumor\u2010to\u2010skin ratios. This formulation was also the most successful in the photodynamic therapy of mice with subcutaneously implanted CT26 murine colon adenocarcinoma tumors. Pharmacokinetic studies in mice and minipigs revealed that with the same low CrEL formulation, the half\u2010life of the photosensitizer in the central compartment was longer in minipigs. Differences in biodistribution with the various formulations, and in pharmacokinetics between the two animal species with the same formulation, are attributed to the interaction of the formulations with low\u2010density lipoproteins (LDLs). Skin photosensitivity studies in rats showed that 30\u2005min exposure of the skin to a solar simulator 7\u2005days after i.v. administration of the fluorinated sulfonamide bacteriochlorin at 1\u2005mg\u2009kg<jats:sup>\u22121<\/jats:sup> did not elicit significant skin reactions.<\/jats:p>","DOI":"10.1002\/cmdc.201300449","type":"journal-article","created":{"date-parts":[[2013,12,27]],"date-time":"2013-12-27T07:57:14Z","timestamp":1388131034000},"page":"390-398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Modulation of Biodistribution, Pharmacokinetics, and Photosensitivity with the Delivery Vehicle of a Bacteriochlorin Photosensitizer for Photodynamic Therapy"],"prefix":"10.1002","volume":"9","author":[{"given":"Raquel","family":"Saavedra","sequence":"first","affiliation":[]},{"given":"Luis B.","family":"Rocha","sequence":"additional","affiliation":[]},{"given":"Janusz M.","family":"D\u0105browski","sequence":"additional","affiliation":[]},{"given":"Luis G.","family":"Arnaut","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2013,12,27]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.12.889"},{"key":"e_1_2_6_2_2","unstructured":"L.\u2005G. Arnaut M.\u2005M. Pereira J.\u2005M. D\u0105browski E.\u2005F.\u2005F. Silva F.\u2005A. Schaberle A.\u2005A. Abreu L.\u2005B. Rocha M.\u2005M. Barsam K. Urbanska G. Stochel C.\u2005M.\u2005A. Brett Chem. Eur. J.\u00ad2014 DOI:."},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1996.tb03093.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2008.11.016"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2011.08.019"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2011.09.085"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.07.025"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02594144"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910480218"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(94)03612-M"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1562\/0031-8655(2002)0750140IVAIVE2.0.CO2"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2005.tb00193.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201100186"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201000524"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1995.tb02387.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1994.tb05083.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/1011-1344(90)80008-L"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1991.18"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1993.tb02962.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1994.414"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1995.tb08629.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1999.tb03316.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600651"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600682"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601101"},{"key":"e_1_2_6_26_2","first-page":"639","volume":"12","author":"Maugain E.","year":"2004","journal-title":"Oncol. Rep."},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1039\/c2md00308b"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200342070-00005"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201200351"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.4.300"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(73)90142-4"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(99)00248-5"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(86)90023-6"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/1011-1344(90)85074-7"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1994.162"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(01)00092-9"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1011-1344(01)00267-6"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-006-0356-9"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00182.x"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1997.502"},{"key":"e_1_2_6_41_2","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1093\/jn\/137.10.2219","volume":"137","author":"Torres\u2010Gonzalez M.","year":"2007","journal-title":"J. Nutr."},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910550213"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1991.tb03935.x"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(01)00171-X"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2005.tb01528.x"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1989.tb09191.x"}],"container-title":["ChemMedChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcmdc.201300449","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.201300449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T16:56:20Z","timestamp":1760288180000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cmdc.201300449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,27]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1002\/cmdc.201300449"],"URL":"https:\/\/doi.org\/10.1002\/cmdc.201300449","archive":["Portico"],"relation":{},"ISSN":["1860-7179","1860-7187"],"issn-type":[{"value":"1860-7179","type":"print"},{"value":"1860-7187","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,27]]},"assertion":[{"value":"2013-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-12-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}