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It is based on a 1,4,7,10\u2010tetraazacyclododecane\u20101,4,7,10\u2010tetraacetic acid macrocycle bearing a triarylphosphine and can be tracked in vivo by using the \u03b3 emission of <jats:sup>153<\/jats:sup>Sm atoms. Notably, the heteroditopic ligand can be selectively metalated with ruthenium at the phosphorus atom despite the presence of other functionalities that are prone to metal coordination. Subsequent labeling with radionuclides such as <jats:sup>153<\/jats:sup>Sm can then be performed easily. The resulting heterobimetallic complex exhibits favorable solubility and stability properties in biologically relevant media. It also shows in vitro cytotoxicity in line with that expected for this type of metallodrug, and is nontoxic to the organism as a whole. 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