{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T20:15:39Z","timestamp":1775074539899,"version":"3.50.1"},"reference-count":135,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T00:00:00Z","timestamp":1413417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nature continues to be the ultimate in nanotechnology, where polymeric nanometer\u2010scale architectures play a central role in biological systems. Inspired by the way nature forms functional supramolecular assemblies, researchers are trying to make nanostructures and to incorporate these into macrostructures as nature does. Recent advances and progress in nanoscience have demonstrated the great potential that nanomaterials have for applications in healthcare. In the realm of drug delivery, nanomaterials have been used in vivo to protect the drug entity in the systemic circulation, ensuring reproducible absorption of bioactive molecules that do not naturally penetrate biological barriers, restricting drug access to specific target sites. Several building blocks have been used in the formulation of nanoparticles. Thus, stability, drug release, and targeting can be tailored by surface modification. Herein the state of the art of stimuli\u2010responsive polymeric nanoparticles are reviewed. Such systems are able to control drug release by reacting to naturally occurring or external applied stimuli. Special attention is paid to the design and nanoparticle formulation of these so\u2010called smart drug\u2010delivery systems. Future strategies for further developments of a promising controlled drug delivery responsive system are also outlined.<\/jats:p>","DOI":"10.1002\/cmdc.201402290","type":"journal-article","created":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T06:33:09Z","timestamp":1413441189000},"page":"24-38","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":156,"title":["Stimuli\u2010Responsive Polymeric Nanoparticles for Nanomedicine"],"prefix":"10.1002","volume":"10","author":[{"given":"Carina I. C.","family":"Crucho","sequence":"first","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2014,10,16]]},"reference":[{"key":"e_1_2_5_1_2","first-page":"265","volume":"8","author":"Ochekpe N. A.","year":"2009","journal-title":"Trop. J. Pharm. Res."},{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2174\/157488410793352003","volume":"5","author":"Leucuta S. E.","year":"2010","journal-title":"Curr. Clin. Pharmacol."},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"7906","DOI":"10.1166\/jnn.2010.3617","volume":"10","author":"Singh S.","year":"2010","journal-title":"J. Nanosci. Nanotechnol."},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1039\/c2cs15327k","volume":"41","author":"Elsabahy M.","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"e_1_2_5_5_2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/mabi.200500178","volume":"6","author":"Paiphansiri U.","year":"2006","journal-title":"Macromol. Biosci."},{"key":"e_1_2_5_6_2","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1023\/A:1007582332491","volume":"17","author":"Lambert G.","year":"2000","journal-title":"Pharm. Res."},{"key":"e_1_2_5_7_2","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1023\/A:1008365716693","volume":"11","author":"Safra T.","year":"2000","journal-title":"Ann. Oncol."},{"key":"e_1_2_5_8_2","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1021\/js980084y","volume":"87","author":"Schroeder U.","year":"1998","journal-title":"J. Pharm. Sci."},{"key":"e_1_2_5_9_2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0378-5173(02)00342-3","volume":"245","author":"Raghuvanshi R. S.","year":"2002","journal-title":"Int. J. Pharm."},{"key":"e_1_2_5_10_2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0168-3659(97)00061-8","volume":"49","author":"Kreuter J.","year":"1997","journal-title":"J. Controlled Release"},{"key":"e_1_2_5_11_2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1046\/j.1365-2141.2003.04395_3.x","volume":"122","author":"Fassas A.","year":"2003","journal-title":"Br. J. Haematol."},{"key":"e_1_2_5_12_2","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0168-3659(95)00164-6","volume":"39","author":"Jean\u2010Christophe L.","year":"1996","journal-title":"J. Controlled Release"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1021\/mp800051m","volume":"5","author":"Alexis F.","year":"2008","journal-title":"Mol. Pharmaceutics"},{"key":"e_1_2_5_14_2","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.biopha.2006.07.093","volume":"60","author":"Toub N.","year":"2006","journal-title":"Biomed. Pharmacother."},{"key":"e_1_2_5_15_2","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1021\/nn102278w","volume":"5","author":"Shokeen M.","year":"2011","journal-title":"ACS Nano"},{"key":"e_1_2_5_16_2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v23.i4.10","volume":"23","author":"Nahar M.","year":"2006","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"key":"e_1_2_5_17_2","doi-asserted-by":"crossref","unstructured":"H.Ding K. T.Yong I.Roy R.Hu F.Wu L.Zhao WC. Law W. Zhao W. Ji L. Liu E.\u2005J. Bergey P.\u2005N. Prasad Nanotechnology\u00ad2011 22 165101\u2013165113.","DOI":"10.1088\/0957-4484\/22\/16\/165101"},{"key":"e_1_2_5_18_2","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1039\/C0SM00412J","volume":"7","author":"Boyer C.","year":"2011","journal-title":"Soft Matter"},{"key":"e_1_2_5_19_2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/978-3-7643-8679-5_8","volume-title":"PEGylated Protein Drugs: Basic Science and Clinical Applications","author":"Webster R.","year":"2009"},{"key":"e_1_2_5_20_2","doi-asserted-by":"crossref","first-page":"5402","DOI":"10.1021\/cr9001403","volume":"109","author":"Boyer C.","year":"2009","journal-title":"Chem. Rev."},{"key":"e_1_2_5_21_2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.nano.2005.12.003","volume":"2","author":"Pinto Reis C.","year":"2006","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"e_1_2_5_22_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-3659(00)00339-4","volume":"70","author":"Soppimath K. S.","year":"2001","journal-title":"J. Controlled Release"},{"key":"e_1_2_5_23_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.colsurfb.2009.09.001","volume":"75","author":"Kumari A.","year":"2010","journal-title":"Colloids Surf. B"},{"key":"e_1_2_5_24_2","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/s11095-008-9800-3","volume":"26","author":"Vauthier C.","year":"2009","journal-title":"Pharm. Res."},{"key":"e_1_2_5_25_2","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.progpolymsci.2011.01.001","volume":"36","author":"Rao J. P.","year":"2011","journal-title":"Prog. Polym. Sci."},{"key":"e_1_2_5_26_2","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1039\/c2cs15344k","volume":"41","author":"Kamaly N.","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"e_1_2_5_27_2","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.addr.2012.01.020","volume":"64","author":"Fleige E.","year":"2012","journal-title":"Adv. Drug Delivery Rev."},{"key":"e_1_2_5_28_2","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/adhm.201200313","volume":"2","author":"Li Y.","year":"2013","journal-title":"Adv. Healthcare Mater."},{"key":"e_1_2_5_29_2","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1039\/c2ib20135f","volume":"5","author":"Zhu L.","year":"2013","journal-title":"Integr. Biol."},{"key":"e_1_2_5_30_2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.jconrel.2012.04.040","volume":"161","author":"Lehner R.","year":"2012","journal-title":"J. Controlled Release"},{"key":"e_1_2_5_31_2","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.progpolymsci.2009.10.004","volume":"35","author":"Motornov M.","year":"2010","journal-title":"Prog. Polym. Sci."},{"key":"e_1_2_5_32_2","doi-asserted-by":"crossref","first-page":"022001","DOI":"10.1088\/1748-6041\/4\/2\/022001","volume":"4","author":"Bawa P.","year":"2009","journal-title":"Biomed. Mater."},{"key":"e_1_2_5_33_2","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/mabi.201100193","volume":"12","author":"Hamidi M.","year":"2012","journal-title":"Macromol. Biosci."},{"key":"e_1_2_5_34_2","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/s00424-010-0865-6","volume":"460","author":"Tresguerres M.","year":"2010","journal-title":"Pfluegers Arch. Eur. J. Physiol."},{"key":"e_1_2_5_35_2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3109\/02656739509022457","volume":"11","author":"Engin K.","year":"1995","journal-title":"Int. J. Hyperthermia"},{"key":"e_1_2_5_36_2","first-page":"1284","volume":"8","author":"Helmlinger G.","year":"2002","journal-title":"Clin. Cancer Res."},{"key":"e_1_2_5_37_2","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/nrc1478","volume":"4","author":"Gatenby R. A.","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"e_1_2_5_38_2","first-page":"1194","volume":"56","author":"Gerweck L. E.","year":"1996","journal-title":"Cancer Res."},{"key":"e_1_2_5_39_2","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nrd3504","volume":"10","author":"Vander Heiden M. G.","year":"2011","journal-title":"Nat. Rev. Drug Discovery"},{"key":"e_1_2_5_40_2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jconrel.2008.05.003","volume":"132","author":"Lee E. S.","year":"2008","journal-title":"J. Controlled Release"},{"key":"e_1_2_5_41_2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/jbm.b.31203","volume":"89","author":"Lu D.","year":"2009","journal-title":"J. Biomed. Mater. Res. Part B"},{"key":"e_1_2_5_42_2","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/nmat2569","volume":"8","author":"MacKay J. A.","year":"2009","journal-title":"Nat. Mater."},{"key":"e_1_2_5_43_2","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.1021\/bm700517z","volume":"8","author":"Jung J.","year":"2007","journal-title":"Biomacromolecules"},{"key":"e_1_2_5_44_2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1021\/mp0500420","volume":"2","author":"Shenoy D.","year":"2005","journal-title":"Mol. Pharmaceutics"},{"key":"e_1_2_5_45_2","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1007\/s11095-005-8343-0","volume":"22","author":"Shenoy D.","year":"2005","journal-title":"Pharm. Res."},{"key":"e_1_2_5_46_2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00280-006-0287-5","volume":"59","author":"Devalapally H.","year":"2007","journal-title":"Cancer Chemother. Pharmacol."},{"key":"e_1_2_5_47_2","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1021\/bm0503571","volume":"7","author":"Sethuraman V. A.","year":"2006","journal-title":"Biomacromolecules"},{"key":"e_1_2_5_48_2","doi-asserted-by":"crossref","first-page":"7297","DOI":"10.1073\/pnas.92.16.7297","volume":"92","author":"Boussif O.","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_2_5_49_2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jconrel.2011.02.031","volume":"152","author":"Liu R.","year":"2011","journal-title":"J. Controlled Release"},{"key":"e_1_2_5_50_2","doi-asserted-by":"crossref","first-page":"275101","DOI":"10.1088\/0957-4484\/24\/27\/275101","volume":"24","author":"Gaspar V. M.","year":"2013","journal-title":"Nanotechnology"},{"key":"e_1_2_5_51_2","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1021\/bm400434h","volume":"14","author":"Zubris K. A. V.","year":"2013","journal-title":"Biomacromolecules"},{"key":"e_1_2_5_52_2","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1021\/mp300144y","volume":"9","author":"Duong H. T. T.","year":"2012","journal-title":"Mol. Pharmaceutics"},{"key":"e_1_2_5_53_2","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1021\/bm401526d","volume":"15","author":"Sagnella S. M.","year":"2014","journal-title":"Biomacromolecules"},{"key":"e_1_2_5_54_2","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/marc.201200029","volume":"33","author":"Liu J.","year":"2012","journal-title":"Macromol. Rapid Commun."},{"key":"e_1_2_5_55_2","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1039\/b926526k","volume":"6","author":"Erwin B. M.","year":"2010","journal-title":"Soft Matter"},{"key":"e_1_2_5_56_2","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1021\/ml400082b","volume":"4","author":"Kim S. J.","year":"2013","journal-title":"ACS Med. Chem. Lett."},{"key":"e_1_2_5_57_2","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1021\/bm500422v","volume":"15","author":"Duong H. T. T.","year":"2014","journal-title":"Biomacromolecules"},{"key":"e_1_2_5_58_2","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.1021\/ic101736e","volume":"50","author":"Salmon D. J.","year":"2011","journal-title":"Inorg. Chem."},{"key":"e_1_2_5_59_2","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1080\/10601320903078263","volume":"46","author":"Han S.\u2010C.","year":"2009","journal-title":"J. Macromol. Sci. Part A"},{"key":"e_1_2_5_60_2","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.ejpb.2011.06.007","volume":"79","author":"Zhang T.","year":"2011","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"e_1_2_5_61_2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ijpharm.2008.12.003","volume":"370","author":"Zhu L.","year":"2009","journal-title":"Int. J. Pharm."},{"key":"e_1_2_5_62_2","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jconrel.2009.10.002","volume":"142","author":"Pradhan P.","year":"2010","journal-title":"J. Controlled Release"},{"key":"e_1_2_5_63_2","doi-asserted-by":"crossref","first-page":"5094","DOI":"10.1021\/nn201171r","volume":"5","author":"Kang H.","year":"2011","journal-title":"ACS Nano"},{"key":"e_1_2_5_64_2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jconrel.2010.10.036","volume":"150","author":"de Smet M.","year":"2011","journal-title":"J. Controlled Release"},{"key":"e_1_2_5_65_2","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1002\/polb.1990.090280609","volume":"28","author":"Bae Y. H.","year":"1990","journal-title":"J. Polym. Sci. Part B"},{"key":"e_1_2_5_66_2","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1021\/bm060182a","volume":"7","author":"Choi S. H.","year":"2006","journal-title":"Biomacromolecules"},{"key":"e_1_2_5_67_2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jconrel.2007.09.011","volume":"125","author":"Lee S. H.","year":"2008","journal-title":"J. Controlled Release"},{"key":"e_1_2_5_68_2","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/jbm.a.31129","volume":"81","author":"Yang M.","year":"2007","journal-title":"J. Biomed. Mater. Res. A"},{"key":"e_1_2_5_69_2","doi-asserted-by":"crossref","first-page":"065104","DOI":"10.1088\/0957-4484\/20\/6\/065104","volume":"20","author":"Li Y.","year":"2009","journal-title":"Nanotechnology"},{"key":"e_1_2_5_69_3","unstructured":"DOI:."},{"key":"e_1_2_5_70_2","doi-asserted-by":"crossref","first-page":"4488","DOI":"10.1016\/j.biomaterials.2007.06.033","volume":"28","author":"Mao Z. W.","year":"2007","journal-title":"Biomaterials"},{"key":"e_1_2_5_71_2","doi-asserted-by":"crossref","first-page":"7779","DOI":"10.1002\/anie.201403147","volume":"53","author":"Hu J.","year":"2014","journal-title":"Angew. Chem. Int. Ed."},{"key":"e_1_2_5_71_3","doi-asserted-by":"crossref","first-page":"7913","DOI":"10.1002\/ange.201403147","volume":"126","year":"2014","journal-title":"Angew. Chem."},{"key":"e_1_2_5_72_2","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1039\/9781849736800-00304","volume-title":"Smart Materials for Drug Delivery","author":"Alatorre\u2010Meda M.","year":"2013"},{"key":"e_1_2_5_73_2","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1111\/j.1751-1097.2008.00530.x","volume":"85","author":"Alvarez\u2010Lorenzo C.","year":"2009","journal-title":"Photochem. Photobiol."},{"key":"e_1_2_5_74_2","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1039\/C4SC01309C","volume":"5","author":"Xu J.","year":"2014","journal-title":"Chem. Sci."},{"key":"e_1_2_5_75_2","doi-asserted-by":"crossref","first-page":"8167","DOI":"10.1021\/ma800648e","volume":"41","author":"Shi D.","year":"2008","journal-title":"Macromolecules"},{"key":"e_1_2_5_76_2","doi-asserted-by":"crossref","first-page":"9540","DOI":"10.1021\/ja102595j","volume":"132","author":"Fomina N.","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"e_1_2_5_77_2","doi-asserted-by":"crossref","first-page":"8590","DOI":"10.1021\/ma201850q","volume":"44","author":"Fomina N.","year":"2011","journal-title":"Macromolecules"},{"key":"e_1_2_5_78_2","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1039\/b922613c","volume":"20","author":"Kim M. S.","year":"2010","journal-title":"J. Mater. Chem."},{"key":"e_1_2_5_79_2","doi-asserted-by":"crossref","first-page":"065702","DOI":"10.1088\/0957-4484\/22\/6\/065702","volume":"22","author":"Cui W.","year":"2011","journal-title":"Nanotechnology"},{"key":"e_1_2_5_79_3","unstructured":"DOI:."},{"key":"e_1_2_5_80_2","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1080\/1539445X.2010.525181","volume":"9","author":"Shen R.","year":"2011","journal-title":"Soft Mater."},{"key":"e_1_2_5_81_2","doi-asserted-by":"crossref","first-page":"9387","DOI":"10.1021\/la301534h","volume":"28","author":"Lv C.","year":"2012","journal-title":"Langmuir"},{"key":"e_1_2_5_82_2","first-page":"35","volume-title":"Handbook of Stimuli\u2010Responsive Materials","author":"Roy D.","year":"2011"},{"key":"e_1_2_5_83_2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev.micro.51.1.179","volume":"51","author":"Raina S.","year":"1997","journal-title":"Annu. Rev. Microbiol."},{"key":"e_1_2_5_84_2","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1039\/C3PY01192E","volume":"5","author":"Huo M.","year":"2014","journal-title":"Polym. Chem."},{"key":"e_1_2_5_85_2","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.colsurfb.2011.06.009","volume":"87","author":"Song N.","year":"2011","journal-title":"Colloids Surf. B"},{"key":"e_1_2_5_86_2","doi-asserted-by":"crossref","first-page":"5223","DOI":"10.1016\/j.biomaterials.2011.03.060","volume":"32","author":"Zhao M.","year":"2011","journal-title":"Biomaterials"},{"key":"e_1_2_5_87_2","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1071\/CH09062","volume":"62","author":"Boyer C.","year":"2009","journal-title":"Aust. J. Chem."},{"key":"e_1_2_5_88_2","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/pola.23208","volume":"47","author":"Liu J.","year":"2009","journal-title":"J. Polym. Sci. Part A"},{"key":"e_1_2_5_89_2","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1021\/bm900817a","volume":"10","author":"Jia Z.","year":"2009","journal-title":"Biomacromolecules"},{"key":"e_1_2_5_90_2","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1021\/bm900646g","volume":"10","author":"Setijadi E.","year":"2009","journal-title":"Biomacromolecules"},{"key":"e_1_2_5_91_2","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1021\/mp400049e","volume":"10","author":"Boyer C.","year":"2013","journal-title":"Mol. Pharmaceutics"},{"key":"e_1_2_5_92_2","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.addr.2008.03.008","volume":"60","author":"Husseini G. A.","year":"2008","journal-title":"Adv. Drug Delivery Rev."},{"key":"e_1_2_5_93_2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jconrel.2010.07.117","volume":"148","author":"Deckers R.","year":"2010","journal-title":"J. Controlled Release"},{"key":"e_1_2_5_94_2","first-page":"54","volume":"31","author":"Schroeder A.","year":"2013","journal-title":"Chim. Oggi"},{"key":"e_1_2_5_95_2","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ijpharm.2009.09.027","volume":"384","author":"Wang Y.","year":"2010","journal-title":"Int. J. Pharm."},{"key":"e_1_2_5_96_2","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/jps.21444","volume":"98","author":"Husseini G. A.","year":"2009","journal-title":"J. Pharm. Sci."},{"key":"e_1_2_5_97_2","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1007\/s11095-008-9786-x","volume":"26","author":"Doiron A. L.","year":"2009","journal-title":"Pharm. Res."},{"key":"e_1_2_5_98_2","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/j.biomaterials.2009.11.044","volume":"31","author":"D\u00edaz\u2010L\u00f3pez R.","year":"2010","journal-title":"Biomaterials"},{"key":"e_1_2_5_99_2","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.ultras.2011.04.003","volume":"51","author":"Mendoza\u2010Mu\u00f1oz N.","year":"2011","journal-title":"Ultrasonics"},{"key":"e_1_2_5_100_2","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ejps.2013.04.004","volume":"50","author":"Kocbek P.","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"key":"e_1_2_5_101_2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/asiamat.2010.6","volume":"2","author":"Boyer C.","year":"2010","journal-title":"NPG Asia Mater."},{"key":"e_1_2_5_102_2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1039\/9781849737623-00225","volume-title":"NanoScience, Vol.\u20052","author":"Dunn A. E.","year":"2013"},{"key":"e_1_2_5_103_2","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.nantod.2008.10.011","volume":"4","author":"Liu T.\u2010Y.","year":"2009","journal-title":"Nano Today"},{"key":"e_1_2_5_104_2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1039\/B815202K","volume":"19","author":"Boyer C.","year":"2009","journal-title":"J. Mater. Chem."},{"key":"e_1_2_5_105_2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1039\/B914063H","volume":"20","author":"Boyer C.","year":"2010","journal-title":"J. Mater. Chem."},{"key":"e_1_2_5_106_2","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1039\/C3SC52838C","volume":"5","author":"Basuki J. S.","year":"2014","journal-title":"Chem. Sci."},{"key":"e_1_2_5_107_2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/mabi.200900291","volume":"10","author":"Lee K.","year":"2010","journal-title":"Macromol. Biosci."},{"key":"e_1_2_5_108_2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.colsurfa.2011.03.051","volume":"384","author":"Arias J. L.","year":"2011","journal-title":"Colloids Surf. A"},{"key":"e_1_2_5_109_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/adma.201190202","volume":"24","author":"Hu S.\u2010H.","year":"2012","journal-title":"Adv. Mater."},{"key":"e_1_2_5_110_2","doi-asserted-by":"crossref","first-page":"14152","DOI":"10.1002\/anie.201306724","volume":"52","author":"N\u2032Guyen T. T. T.","year":"2013","journal-title":"Angew. Chem. Int. Ed."},{"key":"e_1_2_5_110_3","doi-asserted-by":"crossref","first-page":"14402","DOI":"10.1002\/ange.201306724","volume":"125","year":"2013","journal-title":"Angew. Chem."},{"key":"e_1_2_5_111_2","doi-asserted-by":"crossref","first-page":"5933","DOI":"10.1039\/c2cs35103j","volume":"41","author":"Hu J.","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"e_1_2_5_112_2","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.addr.2012.01.002","volume":"64","author":"de La Rica R.","year":"2012","journal-title":"Adv. Drug Delivery Rev."},{"key":"e_1_2_5_113_2","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1002\/adma.201101771","volume":"23","author":"Wen J.","year":"2011","journal-title":"Adv. Mater."},{"key":"e_1_2_5_114_2","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.1016\/j.biomaterials.2013.01.084","volume":"34","author":"Cheng R.","year":"2013","journal-title":"Biomaterials"},{"key":"e_1_2_5_115_2","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/adma.200401057","volume":"17","author":"Soppimath K. S.","year":"2005","journal-title":"Adv. Mater."},{"key":"e_1_2_5_116_2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/adfm.200500611","volume":"17","author":"Soppimath K. S.","year":"2007","journal-title":"Adv. Funct. Mater."},{"key":"e_1_2_5_117_2","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1002\/adma.200601817","volume":"19","author":"Zhang L.","year":"2007","journal-title":"Adv. Mater."},{"key":"e_1_2_5_118_2","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.nano.2011.02.009","volume":"7","author":"Mu B.","year":"2011","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"e_1_2_5_119_2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ijpharm.2012.12.021","volume":"441","author":"Wang A.","year":"2013","journal-title":"Int. J. Pharm."},{"key":"e_1_2_5_120_2","doi-asserted-by":"crossref","first-page":"13859","DOI":"10.1039\/c3ra41410h","volume":"3","author":"Wang Y.","year":"2013","journal-title":"RSC Adv."},{"key":"e_1_2_5_121_2","doi-asserted-by":"crossref","first-page":"6039","DOI":"10.1016\/j.biomaterials.2010.04.016","volume":"31","author":"Shu S.","year":"2010","journal-title":"Biomaterials"},{"key":"e_1_2_5_122_2","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1021\/ma202721s","volume":"45","author":"Jackson A. W.","year":"2012","journal-title":"Macromolecules"},{"key":"e_1_2_5_123_2","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1021\/mp300274g","volume":"9","author":"Remant B. K. C.","year":"2012","journal-title":"Mol. Pharmaceutics"},{"key":"e_1_2_5_124_2","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1039\/B9NR00244H","volume":"2","author":"Guo M.","year":"2010","journal-title":"Nanoscale"},{"key":"e_1_2_5_125_2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.colsurfb.2012.10.041","volume":"103","author":"Yu S.","year":"2013","journal-title":"Colloids Surf. B"},{"key":"e_1_2_5_126_2","doi-asserted-by":"crossref","first-page":"10175","DOI":"10.1021\/nn404407g","volume":"7","author":"Basuki J. S.","year":"2013","journal-title":"ACS Nano"},{"key":"e_1_2_5_127_2","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1039\/C4PY00150H","volume":"5","author":"Dunn A. E.","year":"2014","journal-title":"Polym. Chem."},{"key":"e_1_2_5_128_2","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.actbio.2007.05.011","volume":"3","author":"Zhang J.","year":"2007","journal-title":"Acta Biomater."},{"key":"e_1_2_5_129_2","doi-asserted-by":"crossref","first-page":"5083","DOI":"10.1021\/ma100481s","volume":"43","author":"Rosenbauer E.\u2010M.","year":"2010","journal-title":"Macromolecules"},{"key":"e_1_2_5_130_2","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1039\/c3bm00188a","volume":"1","author":"Wang Y.","year":"2013","journal-title":"Biomater. Sci."},{"key":"e_1_2_5_131_2","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1016\/j.biomaterials.2013.11.057","volume":"35","author":"Yang P.","year":"2014","journal-title":"Biomaterials"}],"container-title":["ChemMedChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcmdc.201402290","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.201402290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T22:18:07Z","timestamp":1760307487000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cmdc.201402290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,16]]},"references-count":135,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1002\/cmdc.201402290"],"URL":"https:\/\/doi.org\/10.1002\/cmdc.201402290","archive":["Portico"],"relation":{},"ISSN":["1860-7179","1860-7187"],"issn-type":[{"value":"1860-7179","type":"print"},{"value":"1860-7187","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,16]]},"assertion":[{"value":"2014-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-10-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}