{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:23:49Z","timestamp":1774682629695,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T00:00:00Z","timestamp":1433203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In a follow\u2010up study to our reports of N\u2010cinnamoylated chloroquine and quinacrine analogues as promising dual\u2010stage antimalarial leads with high in vitro potency against both blood\u2010stage <jats:italic>Plasmodium falciparum<\/jats:italic> and liver\u2010stage <jats:italic>Plasmodium berghei<\/jats:italic>, we decided to investigate the effect of replacing the cinnamoyl moiety with other acyl groups. Thus, a series of N\u2010acylated analogues were synthesized, and their activities against blood\u2010 and liver\u2010stage <jats:italic>Plasmodium<\/jats:italic>\u2005spp. were assessed along with their in vitro cytotoxicities. Although the new N\u2010acylated analogues were found to be somewhat less active and more cytotoxic than their N\u2010cinnamoylated counterparts, they equally displayed nanomolar activities in vitro against blood\u2010stage drug\u2010sensitive and drug\u2010resistant <jats:italic>P.\u2005falciparum<\/jats:italic>, and significant in vitro liver\u2010stage activity against <jats:italic>P.\u2005berghei<\/jats:italic>. Therefore, it is demonstrated that simple N\u2010acylated surrogates of classical antimalarial drugs are promising dual\u2010stage antimalarial leads.<\/jats:p>","DOI":"10.1002\/cmdc.201500164","type":"journal-article","created":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T23:11:00Z","timestamp":1433286660000},"page":"1344-1349","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["N\u2010Cinnamoylation of Antimalarial Classics: Effects of Using Acyl Groups Other than Cinnamoyl toward Dual\u2010Stage 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