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A series of such compounds was prepared by a multicomponent Petasis\u2010borono Mannich reaction starting from salicylaldehyde and its derivatives. The obtained compounds were tested against a large panel of microorganisms, Gram\u2010positive and Gram\u2010negative bacteria, and a yeast. Among the several tertiary amine derivatives tested, indoline\u2010derived aminophenols containing a nitro group at the <jats:italic>para<\/jats:italic>\u2010phenol position showed considerable activity against bacteria tested with minimal inhibitory concentrations as low as 1.36\u2005\u03bc<jats:sc>m<\/jats:sc> against <jats:italic>Staphyloccocus aureus<\/jats:italic> and <jats:italic>Mycobacterium smegmatis<\/jats:italic>. Cytotoxicity of the new <jats:italic>para<\/jats:italic>\u2010nitrophenol derivatives was observed only at concentrations much higher than those required for antibacterial activity.<\/jats:p>","DOI":"10.1002\/cmdc.201600244","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T03:34:20Z","timestamp":1469504060000},"page":"2015-2023","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Multicomponent Petasis\u2010borono Mannich Preparation of Alkylaminophenols and Antimicrobial Activity Studies"],"prefix":"10.1002","volume":"11","author":[{"given":"\u00cdris","family":"Neto","sequence":"first","affiliation":[{"name":"Center for Research in Biosciences &amp; Health Technologies (CBIOS) Universidade Lus\u00f3fona de Humanidades e Tecnologias  1749-024 Lisboa Portugal"}]},{"given":"Joana","family":"Andrade","sequence":"additional","affiliation":[{"name":"Center for Research in Biosciences &amp; Health Technologies (CBIOS) Universidade Lus\u00f3fona de Humanidades e Tecnologias  1749-024 Lisboa Portugal"}]},{"given":"A. 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