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The whole series was screened against the blood stage of a chloroquine\u2010resistant <jats:italic>Plasmodium falciparum<\/jats:italic> strain and the liver stage of <jats:italic>P.\u2005berghei<\/jats:italic>, yielding compounds with dual\u2010stage activity and sub\u2010micromolar potency against erythrocytic parasites. Studies with genetically modified parasites, using a phenotypic assay based on the <jats:italic>P.\u2005falciparum<\/jats:italic> Dd2\u2010<jats:italic>Sc<\/jats:italic>DHODH line, which expresses yeast dihydroorotate dehydrogenase (DHODH), showed that one of the azaaurone derivatives has the potential to inhibit the parasite mitochondrial electron\u2010transport chain. The global urgency in finding new therapies for malaria, especially against the underexplored liver stage, associated with chemical tractability of azaaurones, warrants further development of this chemotype. 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