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Ionic liquids (ILs) have emerged recently as a topic of study by researchers in the pharmaceutical industry in their search for new therapeutic agents. By definition, ILs are organic salts with melting points below 100\u2009\u00b0C that are composed only by ions. Their main advantage lies in the numerous possible combinations of cations and anions, which allow adjustments in their physicochemical properties. The combination between ILs and active pharmaceutical ingredients (APIs) may improve the properties of APIs. In addition, the antitumor properties of these compounds have been described. Several studies have reported the use of ILs in biomedical applications as therapeutic agents, namely as antitumor agents. This review describes the recent proposed applications of ILs as antitumor agents.<\/jats:p>","DOI":"10.1002\/cmdc.201600480","type":"journal-article","created":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T06:14:21Z","timestamp":1480659261000},"page":"11-18","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":106,"title":["The Anticancer Potential of Ionic Liquids"],"prefix":"10.1002","volume":"12","author":[{"given":"Ana Rita","family":"Dias","sequence":"first","affiliation":[{"name":"Ci\u00eancias Qu\u00edmicas e das Biomol\u00e9culas \/ Centro de Investiga\u00e7\u00e3o em Sa\u00fade e Ambiente (CISA) ESS\u2014Escola Superior de Sa\u00fade do Porto do Instituto Polit\u00e9cnico do Porto, Portugal  Rua Dr. Ant\u00f3nio Bernardino de Almeida, 400 4200-072 Porto Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1375-8067","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Costa\u2010Rodrigues","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Farmacologia e Biocompatibilidade Celular Faculdade de Medicina Dent\u00e1ria Universidade do Porto  Rua Dr. Manuel Pereira da Silva 4200-393 Porto Portugal"},{"name":"ESS\u2014Escola Superior de Sa\u00fade do Porto do Instituto Polit\u00e9cnico do Porto, (Portugal)"},{"name":"Instituto Polit\u00e9cnico de Viana do Castelo Escola Superior de Sa\u00fade  Portugal"}]},{"given":"Maria Helena","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Farmacologia e Biocompatibilidade Celular Faculdade de Medicina Dent\u00e1ria Universidade do Porto  Rua Dr. Manuel Pereira da Silva 4200-393 Porto Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1761-117X","authenticated-orcid":false,"given":"Ricardo","family":"Ferraz","sequence":"additional","affiliation":[{"name":"Ci\u00eancias Qu\u00edmicas e das Biomol\u00e9culas \/ Centro de Investiga\u00e7\u00e3o em Sa\u00fade e Ambiente (CISA) ESS\u2014Escola Superior de Sa\u00fade do Porto do Instituto Polit\u00e9cnico do Porto, Portugal  Rua Dr. Ant\u00f3nio Bernardino de Almeida, 400 4200-072 Porto Portugal"},{"name":"UCIBIO-REQUIMTE Departamento de Qu\u00edmica e Bioqu\u00edmica Faculdade de Ci\u00eancias da Universidade do Porto  Rua do Campo Alegre 687 4169-007 Porto Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9920-936X","authenticated-orcid":false,"given":"Cristina","family":"Prud\u00eancio","sequence":"additional","affiliation":[{"name":"Ci\u00eancias Qu\u00edmicas e das Biomol\u00e9culas \/ Centro de Investiga\u00e7\u00e3o em Sa\u00fade e Ambiente (CISA) ESS\u2014Escola Superior de Sa\u00fade do Porto do Instituto Polit\u00e9cnico do Porto, Portugal  Rua Dr. Ant\u00f3nio Bernardino de Almeida, 400 4200-072 Porto Portugal"},{"name":"I3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade Universidade do Porto  Rua Alfredo Allen, 208 4200-135 Porto Portugal"}]}],"member":"311","published-online":{"date-parts":[[2016,12,13]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2md00269h"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1071\/CH06478"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules14093780"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200902184"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2016.02.029"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules17044158"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201100082"},{"key":"e_1_2_6_8_1","first-page":"587","author":"in B. 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