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Most of the treatments currently used for Parkinson's disease \u2013 the second most prevalent \u2013 are only symptomatic. Therefore, it is urgent to develop drugs that are able to act simultaneously on different targets, being able to stop neuronal death and promote the recovery of neuronal populations already affected. In this work, we studied the activity of a series of hybrid molecules, which combine the structure of both coumarin and an alkynylamine group inspired on rasagiline, as MAO inhibitors, antioxidants and neuroprotective agents. Half of the studied hybrids turned out to be selective monoamine oxidase B (<jats:italic>h<\/jats:italic>MAO\u2010B) inhibitors in the low micro\/nanomolar range, demonstrating that positions 3 (compounds <jats:bold>1\u20133<\/jats:bold>) and 7 (compounds <jats:bold>8<\/jats:bold> and <jats:bold>10<\/jats:bold>) of the coumarin scaffold are the most suitable for the incorporation of the alkynylamine chain. All the studied compounds proved to be capable of neutralizing free radicals (DPPH). Finally, the 4\u2010(but\u20102\u2010yn\u20101\u2010ylamino)coumarin (<jats:bold>5<\/jats:bold>) showed neuroprotective effects on glial cells and the 4\u2010methyl\u20107\u2010(pent\u20102\u2010yn\u20101\u2010ylamino)coumarin (<jats:bold>8<\/jats:bold>) inhibited intraneuronal ROS production as well.<\/jats:p>","DOI":"10.1002\/cmdc.202000018","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T04:25:04Z","timestamp":1581308704000},"page":"532-538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Coumarin\u2010Rasagiline Hybrids as Potent and Selective <i>h<\/i>MAO\u2010B Inhibitors, Antioxidants, and Neuroprotective Agents"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3470-8299","authenticated-orcid":false,"given":"Maria J.","family":"Matos","sequence":"first","affiliation":[{"name":"CIQUP\/Department of Chemistry and Biochemistry Faculty of Sciences University of Porto  4169-007 Porto Portugal"},{"name":"Departamento de Qu\u00edmica Org\u00e1nica Facultad de Farmacia Universidade de Santiago de Compostela  15782 Santiago de Compostela Spain"}]},{"given":"Diana M.","family":"Herrera Ibat\u00e1","sequence":"additional","affiliation":[{"name":"Chronic Diseases Pharmacology Group Center for Research in Molecular Medicine and Chronic Diseases University of Santiago de Compostela  15782 Santiago de Compostela Spain"}]},{"given":"Eugenio","family":"Uriarte","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica Facultad de Farmacia Universidade de Santiago de Compostela  15782 Santiago de Compostela Spain"},{"name":"Instituto de Ciencias Qu\u00edmicas Aplicadas Universidad Aut\u00f3noma de Chile  7500912 Santiago Chile"}]},{"given":"Dolores","family":"Vi\u00f1a","sequence":"additional","affiliation":[{"name":"Chronic Diseases Pharmacology Group Center for Research in Molecular Medicine and Chronic Diseases University of Santiago de Compostela  15782 Santiago de Compostela Spain"}]}],"member":"311","published-online":{"date-parts":[[2020,2,27]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0000000000000167"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2210-11-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2016.105"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-017-8523-y"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.05.039"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00220"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00069"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.08.039"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/156802661708170126200430"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201900261"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8MD00446C"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.03.057"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026616666160927154116"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867053507315"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026614666141229124141"},{"key":"e_1_2_7_16_1","first-page":"3173","volume":"17","author":"Delogu G. 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