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Herein, we disclose two novel acridine\u2010based families of compounds that combine the structural features of primaquine and chloroquine. Compounds prepared and studied thus far retained the <jats:italic>in\u2005vitro<\/jats:italic> activity displayed by the parent drugs against the erythrocytic stages of chloroquine\u2010sensitive and \u2010resistant <jats:italic>Plasmodium falciparum<\/jats:italic> strains, and against the hepatic stages of <jats:italic>Plasmodium berghei<\/jats:italic>, hence acting as dual\u2010stage antiplasmodial hits.<\/jats:p>","DOI":"10.1002\/cmdc.202000740","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T01:16:42Z","timestamp":1605921402000},"page":"788-792","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["4,9\u2010Diaminoacridines and 4\u2010Aminoacridines as Dual\u2010Stage Antiplasmodial Hits"],"prefix":"10.1002","volume":"16","author":[{"given":"M\u00e9lanie","family":"Fonte","sequence":"first","affiliation":[{"name":"LAQV-REQUIMTE, Departamento de Qu\u00edmica e Bioqu\u00edmica Faculdade de Ci\u00eancias Universidade do Porto  R. do Campo Alegre 4169-007 Porto Portugal"}]},{"given":"Nat\u00e1lia","family":"Tassi","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Departamento de Qu\u00edmica e Bioqu\u00edmica Faculdade de Ci\u00eancias Universidade do Porto  R. do Campo Alegre 4169-007 Porto Portugal"}]},{"given":"Diana","family":"Fontinha","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes Faculdade de Medicina Universidade de Lisboa  Av. Prof. Egas Moniz 1649-028 Lisboa Portugal"}]},{"given":"In\u00e9s","family":"Bouz\u00f3n\u2010Arn\u00e1iz","sequence":"additional","affiliation":[{"name":"Nanomalaria Group, Institute for Bioengineering of Catalonia (IBEC) The Barcelona Institute of Science and Technology  Baldiri Reixac, 10\u201312 08028 Barcelona Spain"},{"name":"Barcelona Institute for Global Health (ISGlobal) Hospital Cl\u00ednic-Universitat de Barcelona  Carrer del Rossell\u00f3, 132 08036 Barcelona Spain"}]},{"given":"Ricardo","family":"Ferraz","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Departamento de Qu\u00edmica e Bioqu\u00edmica Faculdade de Ci\u00eancias Universidade do Porto  R. do Campo Alegre 4169-007 Porto Portugal"},{"name":"Ci\u00eancias Qu\u00edmicas e das Biomol\u00e9culas Escola Superior de Sa\u00fade Polit\u00e9cnico do Porto  R. Dr. Ant\u00f3nio Bernardino de Almeida 400 4200-072 Porto Portugal"}]},{"given":"Maria J.","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Departamento de Qu\u00edmica e Bioqu\u00edmica Faculdade de Ci\u00eancias Universidade do Porto  R. do Campo Alegre 4169-007 Porto Portugal"}]},{"given":"Xavier","family":"Fern\u00e0ndez\u2010Busquets","sequence":"additional","affiliation":[{"name":"Nanomalaria Group, Institute for Bioengineering of Catalonia (IBEC) The Barcelona Institute of Science and Technology  Baldiri Reixac, 10\u201312 08028 Barcelona Spain"},{"name":"Barcelona Institute for Global Health (ISGlobal) Hospital Cl\u00ednic-Universitat de Barcelona  Carrer del Rossell\u00f3, 132 08036 Barcelona Spain"}]},{"given":"Miguel","family":"Prud\u00eancio","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes Faculdade de Medicina Universidade de Lisboa  Av. 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