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This affords surface\u2010active ionic liquids whose liver\u2010stage antiplasmodial activity is either retained or slightly enhanced, while revealing blood\u2010stage antiplasmodial activity at least one order of magnitude higher than that of the parent compound. These findings open new perspectives towards the cost\u2010effective recycling of classical drugs that are either shelved or in decline, and which is not limited to antimalarial agents.<\/jats:p>","DOI":"10.1002\/cmdc.202100650","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T14:51:20Z","timestamp":1639061480000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Drug\u2010Derived Surface\u2010Active Ionic Liquids: A Cost\u2010Effective Way To Expressively Increase the Blood\u2010Stage Antimalarial Activity of Primaquine"],"prefix":"10.1002","volume":"17","author":[{"given":"Ana Teresa","family":"Silva","sequence":"first","affiliation":[{"name":"LAQV-REQUIMTE Departamento de Qu\u00edmica e Bioqu\u00edmica Faculdade de Ci\u00eancias Universidade do Porto  Rua do Campo Alegre 687 4169-007 Porto Portugal"}]},{"given":"Isabel S.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"CIQ-UP Centro de Investiga\u00e7\u00e3o em Qu\u00edmica da Universidade do Porto Departamento de Qu\u00edmica e Bioqu\u00edmica Faculdade de Ci\u00eancias Universidade do Porto  Rua do Campo Alegre 687 4169-007 Porto Portugal"}]},{"given":"Joana","family":"Gomes","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE Departamento de Qu\u00edmica e Bioqu\u00edmica Faculdade de Ci\u00eancias Universidade do Porto  Rua do Campo Alegre 687 4169-007 Porto Portugal"},{"name":"CIQ-UP Centro de Investiga\u00e7\u00e3o em Qu\u00edmica da Universidade do Porto Departamento de Qu\u00edmica e Bioqu\u00edmica Faculdade de Ci\u00eancias Universidade do Porto  Rua do Campo Alegre 687 4169-007 Porto Portugal"}]},{"given":"Lu\u00edsa","family":"Aguiar","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE Departamento de Qu\u00edmica e Bioqu\u00edmica Faculdade de Ci\u00eancias Universidade do Porto  Rua do Campo Alegre 687 4169-007 Porto Portugal"}]},{"given":"Diana","family":"Fontinha","sequence":"additional","affiliation":[{"name":"IMM\u2013Instituto de Medicinal Molecular Jo\u00e3o Lobo Antunes Faculdade de Medicina Universidade de Lisboa  Av. 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