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The anti\u2010trypanosome and anticancer activities were investigated in\u2005vitro on <jats:italic>Trypanosoma cruzi<\/jats:italic> and in two human cancer cell lines (ovarian OVCAR3 and prostate PC3). To test the selectivity toward parasites and cancer cells, the cytotoxicity on normal monkey kidney VERO and human dermal fibroblasts HDF cells was also evaluated. The new heteroleptic complexes were more cytotoxic on <jats:italic>T.\u2005cruzi<\/jats:italic> and chemoresistant prostate PC3 cells than the benchmark drugs nifurtimox and cisplatin. The compounds also showed a high level of cellular internalization by the OVCAR3 cells and, in particular, those containing the dppe phosphane showed activation of the cell death mechanism via apoptosis. On the other hand, the production of reactive oxygen species induced by these complexes was not evident.<\/jats:p>","DOI":"10.1002\/cmdc.202300074","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T14:00:23Z","timestamp":1682431223000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Copper(I)\u2010Thiosemicarbazone Complexes with Dual Anticancer and Antiparasitic Activity"],"prefix":"10.1002","volume":"18","author":[{"given":"Jo\u00e3o Franco","family":"Machado","sequence":"first","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural Institute of Molecular Sciences Faculdade de Ci\u00eancias Universidade de Lisboa  Campo Grande 1749-016 Lisboa Portugal"},{"name":"Departamento de Qu\u00edmica e Bioqu\u00edmica Faculdade de Ci\u00eancias Universidade de Lisboa  Campo Grande 1749-016 Lisboa Portugal"}]},{"given":"Fernanda","family":"Marques","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias e Tecnologias Nucleares Instituto Superior T\u00e9cnico Universidade de Lisboa  Estrada Nacional 2695-066 Bobadela LRS Portugal"},{"name":"Departamento de Engenharia e Ci\u00eancias Nucleares Instituto Superior T\u00e9cnico Universidade de Lisboa  Estrada Nacional 2695-066 Bobadela LRS Portugal"}]},{"given":"Teresa","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Departamento de Engenharia e Ci\u00eancias Nucleares Instituto Superior T\u00e9cnico Universidade de Lisboa  Estrada Nacional 2695-066 Bobadela LRS Portugal"},{"name":"iBB \u2013 Instituto de Bioengenharia e Bioci\u00eancias Instituto Superior T\u00e9cnico Universidade de Lisboa  Av. 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