{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T11:12:44Z","timestamp":1767611564654,"version":"build-2065373602"},"reference-count":147,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2024,12,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Phosphate\u2010containing glycolipids (PcGL) are scarcer than the better understood glycolipids. They are composed of arrangements of phosphate, carbohydrates and glycerol units and are always found associated with lipids. PcGL are often found associated with cell membranes, suggesting they play roles in cell membrane structure and intercellular interactions. This article aims to provide an up\u2010to\u2010date overview of the existing knowledge and research on PcGL, emphasizing their synthesis and wide range of biological activities. When it comes to the synthesis of PcGL compounds, the strategies for glycosylation mainly rely on the thioglycoside donor, the trichloroacetamidate donor and halide donor strategies, while phosphorylation is stapled and falls on either phosphite chemistry or phosphoryl chloride chemistry. Certain bacteria utilize PcGLs in their pathogenicity, triggering an inflammatory response within the host's defense mechanisms. The best\u2010known examples of these structures are teichoic acids, lipopolysaccharide and the capsular polysaccharide found in bacteria, all of which are frequently implicated in bacterial infections. Given the degree of variability within PcGL structures, they were found to display a wide range of bioactivities. PcGL compounds were found to: (1) have anti\u2010metastatic properties, (2) behave as agonists or antagonists of platelet aggregation, (3) be mostly pro\u2010inflammatory, (4) display antifungal and antibiotic activity and (5) have neurogenic activity.<\/jats:p>","DOI":"10.1002\/cmdc.202400315","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T07:13:45Z","timestamp":1721373225000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Phosphate\u2010Containing Glycolipids: A Review on Synthesis and Bioactivity"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0224-8045","authenticated-orcid":false,"given":"Lu\u00eds","family":"Pinheiro","sequence":"first","affiliation":[{"name":"Department of Chemistry NOVA School of Science and Technology, LAQV-REQUIMTE  Campus da Caparica 2825-149 Caparica Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9114-9967","authenticated-orcid":false,"given":"Marisa","family":"Freitas","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy University of Porto, LAQV-REQUIMTE, Faculty of Pharmacy, University of Porto  4050-313 Porto Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7312-8596","authenticated-orcid":false,"given":"Paula S.","family":"Branco","sequence":"additional","affiliation":[{"name":"Department of Chemistry NOVA School of Science and Technology, LAQV-REQUIMTE  Campus da Caparica 2825-149 Caparica Portugal"}]}],"member":"311","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2007.05.001"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cww086"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/md16090294"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/md12063634"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00270F"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-092412-155620"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)41583-4"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-2516-9_2"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuv008"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/B916088D"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1134\/S1068162021010258"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.896187"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.checat.2022.10.019"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/catal13101359"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cber.190103401162"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.2c00029"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2014.06.009"},{"key":"e_1_2_9_18_1","first-page":"14","volume":"28","author":"Escopy S.","year":"2022","journal-title":"Chem. \u2013 A Eur. J."},{"key":"e_1_2_9_19_1","unstructured":"A.\u2005T. Carmona A.\u2005J. Moreno-Vargas I. Robina Adv. Org. Synth.2013 5238\u2013295."},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2022.972429"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/10426507.2016.1217221"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02464-4"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf990554p"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2004.10.006"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(97)00020-4"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00128a043"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(20)30105-8"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajoc.202000357"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/md17020103"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.177.18.5327-5333.1995"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.9b01229"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.2c02419"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8OB00469B"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2006.10.006"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2md20207g"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02464-4"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2008.04.036"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2008.06.041"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.201600839"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202102176"},{"key":"e_1_2_9_41_1","unstructured":"S. Antonopoulou Study of compounds with PAF-like activity and PAF-inhibitors from natural (human blood and Urtica dioica) and synthetic sources University of Athens1994."},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00126a066"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6443"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.8.70"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiosc.2009.09.049"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.2.457-462.1991"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M600034-JLR200"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-014-3946-z"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035067"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201204550"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3ob40899j"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.0c00487"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.177.18.5334-5337.1995"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.178.7.2065-2070.1996"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201406529"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.2c01815"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.47.687"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.49.695"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.52.1140"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.01044.x"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986712798992039"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02535566"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.2174\/156800911798073069"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1232503100"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2006.01.019"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.07.065"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190902934928"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.07106.x"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20081896"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab3516"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2021.06.090"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002100"},{"key":"e_1_2_9_73_1","unstructured":"Novel class of phosphocholine derivatives having antifungal activity WO1994008563\u2005A1 1994."},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.30.3.271"},{"key":"e_1_2_9_75_1","first-page":"511","volume":"117","author":"Dawson M. S.","year":"1993","journal-title":"Arch. Pathol. Lab. Med."},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.1992.8.1863"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00573-3"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2003.03719.x"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.02.079"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(97)00135-X"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.112.6.2135"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2001.tb10664.x"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)39012-9"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10719-007-9088-2"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(01)00487-X"},{"key":"e_1_2_9_86_1","doi-asserted-by":"crossref","unstructured":"Y. Ito J.\u2005L. Vela F. Matsumura H. Hoshino A. Tyznik H. Lee E. Girardi D.\u2005M. Zajonc R. Liddington M. Kobayashi X. Bao J. Bugaytsova T. Bor\u00e9n R. Jin Y. Zong P.\u2005H. Seeberger J. Nakayama M. Kronenberg M. Fukuda PLoS One2013 8 e78191.","DOI":"10.1371\/journal.pone.0078191"},{"key":"e_1_2_9_87_1","doi-asserted-by":"crossref","unstructured":"M. Nagata K. Toyonaga E. Ishikawa S. Haji N. Okahashi M. Takahashi Y. Izumi A. Imamura K. Takato\u2005Hideharu\u2005Ishida S. Nagai P. Illarionov B.\u2005L. Stocker M.\u2005S.\u2005M. Timmer D.\u2005G.\u2005M. Smith S.\u2005J. Williams T. Bamba T. Miyamoto M. Arita B.\u2005J. Appelmelk S. Yamasaki J. Exp. Med.2021 218 e20200815.","DOI":"10.1084\/jem.20200815"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099250"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01155-13"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-016-0804-y"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(02)00226-8"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000092268.01859.0d"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.3.393"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32989-7"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-092412-155620"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5396.2085"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-007-0069-0"},{"key":"e_1_2_9_98_1","doi-asserted-by":"crossref","unstructured":"X. Liu S. Yin Y. Chen Y. Wu W. Zheng H. Dong Y. Bai Y. Qin J. Li S. Feng P. Zhao Mol. Med. Rep.2024.https:\/\/doi.org\/10.3892\/mmr.2018.8542.","DOI":"10.3892\/mmr.2018.8542"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20236008"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1177\/24705470221076390"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.09.051"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1240988"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.86.322"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199701093360202"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.6.5.723"},{"key":"e_1_2_9_106_1","doi-asserted-by":"crossref","unstructured":"H. Heine A. Zamyatina Pharmaceuticals2022 16 23\u201349.","DOI":"10.3390\/ph16010023"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1586\/erv.11.8"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2023.08.005"},{"key":"e_1_2_9_109_1","doi-asserted-by":"crossref","unstructured":"E.\u2005R. Moxon J.\u2005S. Kroll The Role of Bacterial Polysaccharide Capsules as Virulence Factors. In: Bacterial Capsules. Current Topics in Microbiology and Immunology eds. K. Jann B. Jann Springer Berlin Heidelberg1990 150 65\u201385.","DOI":"10.1007\/978-3-642-74694-9_4"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1159\/000081689"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.3.1244-1255.2001"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1985.tb09246.x"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2015.01.013"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000348"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M103908200"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303446200"},{"key":"e_1_2_9_117_1","doi-asserted-by":"crossref","unstructured":"Z. Zhang I.\u2005R. Ollmann X. Ye R. Wischnat T. Baasov C. Wong J. Am. Chem. Soc.1999 121 734\u2013753.","DOI":"10.1021\/ja982232s"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2016.10.009"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/jccs.201300481"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2004.04.016"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.10.012"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01256-08"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403787101"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2024.1353688"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1988.tb02743.x"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176038"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.17.5328-5332.2003"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05559-11"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M608228200"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi992462z"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2009.05.010"},{"key":"e_1_2_9_132_1","doi-asserted-by":"crossref","unstructured":"P. Lopalco S. Lobasso M. Baronio R. Angelini Impact of Lipidomics on the Microbial World of Hypersaline Environments. In:Halophiles Hypersaline Environments eds. Ventosa A. Oren A. Ma Y. Springer Berlin Heidelberg Berlin Heidelberg2011.","DOI":"10.1007\/978-3-642-20198-1_6"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M300329-JLR200"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2003.08.001"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2015.06.004"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(73)90174-4"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(75)90009-0"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592324.2016.1152438"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.108.060053"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1111\/tpj.12547"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(95)00185-9"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi8006324"},{"key":"e_1_2_9_143_1","first-page":"734","volume":"5","author":"Wallhausser K. H.","year":"1965","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja065907x"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(80)80082-2"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1039\/c001461n"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadva.2022.100065"}],"container-title":["ChemMedChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.202400315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T17:05:40Z","timestamp":1760288740000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cmdc.202400315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,3]]},"references-count":147,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2024,12,16]]}},"alternative-id":["10.1002\/cmdc.202400315"],"URL":"https:\/\/doi.org\/10.1002\/cmdc.202400315","archive":["Portico"],"relation":{},"ISSN":["1860-7179","1860-7187"],"issn-type":[{"type":"print","value":"1860-7179"},{"type":"electronic","value":"1860-7187"}],"subject":[],"published":{"date-parts":[[2024,10,3]]},"assertion":[{"value":"2024-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202400315"}}