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SC can be found in nature or can be chemically synthesized in the laboratory. As their presence in nature is scarce, the synthetic origin is the most common. Two types of SC are known: 2\u2010styrylchromones and 3\u2010styrylchromones. However, 2\u2010styrylchromones are the most common, being more broadly found in nature and whose chemical synthesis is more commonly described. A wide variety of SC has been described in the literature, with different substituents in different positions, the majority of which are distributed on the A\u2010 and\/or B\u2010rings. Over the years, several biological activities have been attributed to SC. This work presents a comprehensive review of the biological activities attributed to SC and their structure\u2010activity relationship, based on a published literature search, since 1989. The following biological activities are thoroughly reviewed and discussed in this review: antioxidant, antiallergic, antiviral, antibacterial, antifungal, anti\u2010inflammatory and antitumoral, affinity and selectivity for A<jats:sub>3<\/jats:sub> adenosine receptors, neuroprotective, and <jats:italic>\u03b1<\/jats:italic>\u2010glucosidase inhibition. In general, SC are composed by a promising scaffold with great potential for the development of new drugs.<\/jats:p>","DOI":"10.1002\/cmdc.202400782","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T14:08:19Z","timestamp":1730383699000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Styrylchromones: Biological Activities and Structure\u2010Activity Relationship"],"prefix":"10.1002","volume":"20","author":[{"given":"Mariana","family":"Lucas","sequence":"first","affiliation":[{"name":"LAQV REQUIMTE Laboratory of Applied Chemistry Department of Chemical Sciences Faculty of Pharmacy University of Porto  Rua de Jorge Viterbo Ferreira n\u00b0 228 4050-313 Porto Portugal"}]},{"given":"Marisa","family":"Freitas","sequence":"additional","affiliation":[{"name":"LAQV REQUIMTE Laboratory of Applied Chemistry Department of Chemical Sciences Faculty of Pharmacy University of Porto  Rua de Jorge Viterbo Ferreira n\u00b0 228 4050-313 Porto Portugal"}]},{"given":"Artur M. 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