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The reaction of 2\u2010chloro\u20102\u2032,3\u2032,5\u2032\u2010tri\u2010<jats:italic>O<\/jats:italic>\u2010acetyladenosine <jats:bold>1<\/jats:bold> with Pt(PPh<jats:sub>3<\/jats:sub>)<jats:sub>4<\/jats:sub> by C\u2212Cl oxidative addition yields complex <jats:bold>2<\/jats:bold>, with a Pt<jats:sup>II<\/jats:sup> center bond to the C\u20102 of the purine ring. Complex <jats:bold>2<\/jats:bold> reacts with methyl iodide to yield N\u2010heterocyclic carbene <jats:bold>3<\/jats:bold>, which is subsequently deprotected under basic conditions to provide N\u2010heterocyclic carbene <jats:bold>4<\/jats:bold>, bearing a fully deprotected ribose. The compounds are tested for their cytotoxic activity in five different cell lines: L929, HEK293, A375, MDA\u2010MB\u2010231, and MCF\u20107. Among the platinum compounds, compound <jats:bold>2<\/jats:bold>, the neutral compound bearing an anionic adenosyl ligand, provides the highest cytotoxic activity, particularly against the A375 and MDA\u2010MB\u2010231 cell lines. Encapsulation of compound <jats:bold>2<\/jats:bold> with nanostructured lipid carriers does not lead to an improvement in the cytotoxic activity.<\/jats:p>","DOI":"10.1002\/cmdc.202500368","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T12:53:21Z","timestamp":1749041601000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Platinum N\u2010Heterocyclic Carbene Complexes Based on Adenosine: Synthesis and Antiproliferative Studies"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4182-3770","authenticated-orcid":false,"given":"Giulia","family":"Orsini","sequence":"first","affiliation":[{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Antonio Xavier Universidade Nova de Lisboa  Avenida da Republica s\/n 2780\u2010157 Oeiras 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