{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T20:05:33Z","timestamp":1794168333258,"version":"4.8.0"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T00:00:00Z","timestamp":1419292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000869","name":"Susan G. Komen for the Cure","doi-asserted-by":"publisher","award":["20102790"],"award-info":[{"award-number":["20102790"]}],"id":[{"id":"10.13039\/100000869","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2015,4,15]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Premenopausal women diagnosed with breast cancer are at risk for psychological and behavioral disturbances after cancer treatment. Targeted interventions are needed to address the needs of this vulnerable group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This randomized trial provided the first evaluation of a brief, mindfulness\u2010based intervention for younger breast cancer survivors designed to reduce stress, depression, and inflammatory activity. Women diagnosed with early stage breast cancer at or before age 50 who had completed cancer treatment were randomly assigned to a 6\u2010week Mindful Awareness Practices (MAPS) intervention group (n\u2009=\u200939) or to a wait\u2010list control group (n\u2009=\u200932). Participants completed questionnaires before and after the intervention to assess stress and depressive symptoms (primary outcomes) as well as physical symptoms, cancer\u2010related distress, and positive outcomes. Blood samples were collected to examine genomic and circulating markers of inflammation. Participants also completed questionnaires at a 3\u2010month follow\u2010up assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In linear mixed models, the MAPS intervention led to significant reductions in perceived stress (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.004) and marginal reductions in depressive symptoms (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.094), as well as significant reductions in proinflammatory gene expression (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.009) and inflammatory signaling (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.001) at postintervention. Improvements in secondary outcomes included reduced fatigue, sleep disturbance, and vasomotor symptoms and increased peace and meaning and positive affect (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.05 for all). Intervention effects on psychological and behavioral measures were not maintained at the 3\u2010month follow\u2010up assessment, although reductions in cancer\u2010related distress were observed at that assessment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      A brief, mindfulness\u2010based intervention demonstrated preliminary short\u2010term efficacy in reducing stress, behavioral symptoms, and proinflammatory signaling in younger breast cancer survivors.\n                      <jats:bold>\n                        <jats:italic>Cancer<\/jats:italic>\n                        2015;121:1231\u20131240.\n                      <\/jats:bold>\n                      \u00a9\n                      <jats:italic>2014 American Cancer Society<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  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