{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T02:17:24Z","timestamp":1776997044571,"version":"3.51.4"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["aces.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemNanoMat"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This work aimed at studying the self\u2010assembly of lignin macromolecules towards lignin nanoparticles (LNPs) with green solvents and shedding light on a tailor\u2010made production of LNPs through a meticulous study of different variables. The methodology (antisolvent to lignin solution \u2013 method A; or lignin solution to antisolvent \u2013 method B), the lignin solvent, the flow rate of solvent\/antisolvent addition, the lignin solution loading and the washing step (centrifugation vs dialysis) were examined. Remarkably, method B enabled achieving desired LNPs (127.4\u2013264.9\u2005nm), while method A induced the formation of lignin microparticles (582.8\u20137820\u2005nm). Among lignin solvents, ethanol allowed the preparation of LNPs with the lowest hydrodynamic diameter (method B=127.4\u2005nm), while the largest particles (method A=7820\u2005nm) were obtained with ethylene glycol. These latest particles were characterized as heterogeneous, irregular, and highly aggregated when compared for instance with \u03b3\u2010valerolactone counterparts, which showed the most homogeneous (PDI=0.057\u20130.077) and spherical particles. Moreover, decreasing lignin solution loading enabled the reduction on LNP size and Zeta potential. Dialysed samples allowed the formation of LNPs with lower hydrodynamic size, reduced aggregation, and higher homogeneity. Furthermore, dialysis provided high stability to LNPs, avoiding particle coalescent phenomenon.<\/jats:p>","DOI":"10.1002\/cnma.202400010","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T06:14:31Z","timestamp":1705472071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Sustainable Tailoring of Lignin Nanoparticles Assisted by Green Solvents"],"prefix":"10.1002","volume":"10","author":[{"given":"F\u00e1bio","family":"Almeida","sequence":"first","affiliation":[{"name":"CICECO Department of Chemistry University of Aveiro, Campus Universit\u00e1rio de Santiago  3810-193 Aveiro Portugal"}]},{"given":"Ana","family":"Margarida","sequence":"additional","affiliation":[{"name":"CICECO Department of Chemistry University of Aveiro, Campus Universit\u00e1rio de Santiago  3810-193 Aveiro Portugal"}]},{"given":"Nalin","family":"Seixas","sequence":"additional","affiliation":[{"name":"CICECO Department of Chemistry University of Aveiro, Campus Universit\u00e1rio de Santiago  3810-193 Aveiro Portugal"}]},{"given":"Ricardo J. B.","family":"Pinto","sequence":"additional","affiliation":[{"name":"CICECO Department of Chemistry University of Aveiro, Campus Universit\u00e1rio de Santiago  3810-193 Aveiro Portugal"}]},{"given":"Armando J. D.","family":"Silvestre","sequence":"additional","affiliation":[{"name":"CICECO Department of Chemistry University of Aveiro, Campus Universit\u00e1rio de Santiago  3810-193 Aveiro Portugal"}]},{"given":"Andr\u00e9 M.","family":"Da Costa Lopes","sequence":"additional","affiliation":[{"name":"CICECO Department of Chemistry University of Aveiro, Campus Universit\u00e1rio de Santiago  3810-193 Aveiro Portugal"},{"name":"CECOLAB \u2013 Collaborative Laboratory Towards Circular Economy  R. Nossa Senhora da Concei\u00e7\u00e3o 3405-155 Oliveira do Hospital 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