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The aggregation behavior of these SAILs in water, as well as their adsorption at solution\/air interface, were studied by assessing surface tension and conductivity. The CMC values obtained (0.03\u20136.0\u2005mM) show a high propensity of these compounds to self\u2010aggregate in aqueous media. Their thermal properties were also characterized, namely the melting point and decomposition temperature by using DSC and TGA, respectively. Furthermore, the toxicity of these SAILs was evaluated using the marine bacteria <jats:italic>Aliivibrio fischeri<\/jats:italic> (Gram\u2010negative). According to the EC<jats:sub>50<\/jats:sub> values obtained (0.3\u20132.7\u2005mg\u2009L<jats:sup>\u22121<\/jats:sup>), the surface\u2010active compounds tested should be considered \u201ctoxic\u201d or \u201chighly toxic\u201d. Their ability to induce cell disruption of <jats:italic>Escherichia coli<\/jats:italic> cells (also Gram\u2010negative), releasing the intracellular green fluorescent protein (GFP) produced, was investigated. The results clearly evidence the capability of these SAILs to act as cell disruption agents.<\/jats:p>","DOI":"10.1002\/cphc.201801127","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T11:46:38Z","timestamp":1548330398000},"page":"727-735","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Synthesis and Characterization of Surface\u2010Active Ionic Liquids Used in the Disruption of <i>Escherichia Coli<\/i> Cells"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7686-5970","authenticated-orcid":false,"given":"T\u00e2nia E.","family":"Sintra","sequence":"first","affiliation":[{"name":"Department of Chemistry CICECO \u2013 Aveiro Institute of Materials University of Aveiro Campus Universit\u00e1rio de Santiago  3810-193 Aveiro Portugal"}]},{"given":"Miguel","family":"Vilas","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry Faculty of Chemistry University of Vigo Marcosende, As Lagoas  36310 Vigo Spain"}]},{"given":"Margarida","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Chemistry CICECO \u2013 Aveiro Institute of Materials University of Aveiro Campus Universit\u00e1rio de Santiago  3810-193 Aveiro Portugal"}]},{"given":"S\u00f3nia P. 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