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Here, we studied the dissociative interaction of free electrons with CoQ<jats:sub>0<\/jats:sub>, the smallest ubiquinone derivative with no isoprenyl units, and its fully reduced form, 2,3\u2010dimethoxy\u20105\u2010methylhydroquinone (CoQ<jats:sub>0<\/jats:sub>H<jats:sub>2<\/jats:sub>), an ubiquinol derivative. The anionic products produced upon dissociative electron attachment (DEA) were detected by quadrupole mass spectrometry and studied theoretically through quantum chemical and electron scattering calculations. Despite the structural similarity of the two studied molecules, remarkably only a few DEA reactions are present for both compounds, such as abstraction of a neutral hydrogen atom or the release of a negatively charged methyl group. While the loss of a neutral methyl group represents the most abundant reaction observed in DEA to CoQ<jats:sub>0<\/jats:sub>, this pathway is not observed for CoQ<jats:sub>0<\/jats:sub>H<jats:sub>2<\/jats:sub>. Instead, the loss of a neutral OH radical from the CoQ<jats:sub>0<\/jats:sub>H<jats:sub>2<\/jats:sub> temporary negative ion is observed as the most abundant reaction channel. Overall, this study gives insights into electron attachment properties of simple derivatives of more complex molecules found in biochemical pathways.<\/jats:p>","DOI":"10.1002\/cphc.202100834","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T00:29:25Z","timestamp":1644539365000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Formation of Temporary Negative Ions and Their Subsequent Fragmentation upon Electron Attachment to CoQ<sub>0<\/sub> and CoQ<sub>0<\/sub>H<sub>2<\/sub>"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8648-9924","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Ameixa","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Ionenphysik und Angewandte Physik Leopold-Franzens Universit\u00e4t Innsbruck  Technikerstra\u00dfe 25 6020 Innsbruck Austria"},{"name":"Center for Biomolecular Sciences Innsbruck (CMBI) Leopold-Franzens Universit\u00e4t Innsbruck  Technikerstra\u00dfe 25 6020 Innsbruck Austria"},{"name":"Centre of Physics and Technological Research Departamento de F\u00edsica Faculdade de Ci\u00eancias e Tecnologia Universidade NOVA de Lisboa  2829-516 Caparica Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6200-8361","authenticated-orcid":false,"given":"Eugene","family":"Arthur\u2010Baidoo","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Ionenphysik und Angewandte Physik Leopold-Franzens Universit\u00e4t Innsbruck  Technikerstra\u00dfe 25 6020 Innsbruck Austria"},{"name":"Center for Biomolecular Sciences Innsbruck (CMBI) Leopold-Franzens Universit\u00e4t Innsbruck  Technikerstra\u00dfe 25 6020 Innsbruck Austria"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2066-1303","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Pereira\u2010da\u2010Silva","sequence":"additional","affiliation":[{"name":"Centre of Physics and Technological Research Departamento de F\u00edsica Faculdade de Ci\u00eancias e Tecnologia Universidade NOVA de Lisboa  2829-516 Caparica Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3260-5739","authenticated-orcid":false,"given":"J\u00falio C.","family":"Ruivo","sequence":"additional","affiliation":[{"name":"Instituto de F\u00edsica Universidade de S\u00e3o Paulo  Rua do Mat\u00e3o 1731 05508-090 S\u00e3o Paulo Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5812-0342","authenticated-orcid":false,"given":"M\u00e1rcio","family":"T. do N. 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