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It is shown that acid, aldehyde, and cyanide components can be varied yielding materials with precise structure and tunable stiffness. Additionally, the resulting hydrogels were proven extremely robust to consecutive drying\u2010swelling cycles. This property was explored to develop a reversible humidity colorimetric sensor gel. Overall, this work demonstrates the application of the four\u2010component Ugi reaction as a powerful tool to quickly generate crosslinked gels with precise control in chemical composition.<\/jats:p>","DOI":"10.1002\/cplu.202000743","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T04:26:49Z","timestamp":1608265609000},"page":"2737-2741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Versatile and Tunable Poly(Ethylene Glycol)\u2010Based Hydrogels Crosslinked through the Ugi Reaction"],"prefix":"10.1002","volume":"85","author":[{"given":"In\u00eas","family":"Padr\u00e3o","sequence":"first","affiliation":[{"name":"UCIBIO, Chemistry Department School of Science and Technology NOVA University of Lisbon  Campus Caparica 2829\u2013516 Caparica Portugal"}]},{"given":"Cl\u00e1udia S. 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