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It has been shown that the efficiency of this dual antimicrobial therapy is highly dependent on the structure of the photosensitizer, being tetrapyrrolic macrocycles the ones with most promising results. There are a few review articles in the recent literature describing the main microbiological results concerning this dual inactivation of bacteria, but none of them focus on the synthetic processes of these photosensitizers and their remarkable chemical versatility. Therefore, herein we present an overview on synthetic methodologies for preparation of tetrapyrrolic macrocycles and their conjugates with antibiotics or antimicrobial peptides, for use in dual inactivation of bacteria. This review will be divided in two sections concerning the physical or covalent combinations of PS with antibiotic\/cationic peptides, followed by brief critical analysis on their corresponding antimicrobial outcomes.<\/jats:p>","DOI":"10.1002\/cplu.202200228","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T07:53:50Z","timestamp":1664524430000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Synthesis of Photosensitizers Based on Tetrapyrrolic Macrocycles for Combination with Antibiotics: Dual Inactivation of Bacteria"],"prefix":"10.1002","volume":"87","author":[{"given":"Rafael T.","family":"Aroso","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Universidade de Coimbra  Rua Larga 3004-535 Coimbra Portugal"}]},{"given":"Giusi","family":"Piccirillo","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Universidade de Coimbra  Rua Larga 3004-535 Coimbra Portugal"}]},{"given":"Lucas D.","family":"Dias","sequence":"additional","affiliation":[{"name":"Grupo de Qu\u00edmica Te\u00f3rica e Estrutural de An\u00e1polis Universidade Estadual de Goi\u00e1s  Br 153, N\u00b0 3105 75132-903 An\u00e1polis-GO Brazil"},{"name":"Laborat\u00f3rio de Novos Materiais Universidade Evang\u00e9lica de Goi\u00e1s  Av. 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