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The biocompatibility of the resulting photosensitizers (PS) was enhanced by increasing their solubility in water through their peripheral and\/or axial functionalization with polyether chains (PEG). All compounds generated singlet oxygen, with peripherally unsubstituted phthalocyanines displaying higher <jats:sup>1<\/jats:sup>O<jats:sub>2<\/jats:sub> yields. In\u2005vitro assays using the human bladder cancer cell line HT\u20101376 revealed that peripherally unsubstituted phthalocyanines were also more efficient in terms of cellular uptake and therefore, phototoxicity. The protected carbohydrate functional groups at the axial positions did not improve significantly the cellular uptake of PSs, although they increased their photodynamic efficiency. 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