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We examined whether A\u03b2 accumulation in cognitive\u2010emotional regions was associated with post\u2010pandemic psychiatric symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This prospective cohort study included 115 cognitively unimpaired ALzheimer's and FAmilies participants (69 [60%] women, mean [SD] age 64.9 [4.8] years). Amyloid beta (A\u03b2) change was examined in anterior cingulate, posterior cingulate, superior parietal, medial orbitofrontal gyri, and insula using two [18F]flutemetamol positron emission tomography (PET) scans. Outcomes were pandemic\u2010related post\u2010traumatic distress (Impact of Events Scale Revised [IES\u2010R]; total, intrusive, avoidance, and hyperarousal symptoms) and anxious\u2010depressive symptoms (Hospital Anxiety and Depression Scale [HADS]; mean follow\u2010up: 3.62 years [SD\u00a0=\u00a00.68]). Linear regression and voxel\u2010wise analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A\u03b2 accumulation across anterior cingulate (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a040.29,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.036), posterior cingulate (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a029.52,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.012), superior parietal (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a035.58,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.036), and medial orbitofrontal gyri (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a035.08,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.036) was associated with post\u2010pandemic intrusive symptoms only, independent of baseline anxious\u2010depressive symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>A\u03b2 accumulation in cognitive\u2010emotional regions may increase vulnerability to intrusive symptoms, highlighting their potential as early clinical markers in AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70410","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T10:09:10Z","timestamp":1787047750000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Regional amyloid accumulation, post\u2010traumatic distress, and intrusive symptoms in cognitively unimpaired older adults at risk for Alzheimer's"],"prefix":"10.1002","volume":"18","author":[{"given":"Eleni","family":"Palpatzis","sequence":"first","affiliation":[{"name":"Barcelona Institute for Global Health (ISGlobal)  Barcelona Spain"},{"name":"University of Pompeu Fabra (UPF)  Barcelona Spain"},{"name":"Pasqual Maragall Foundation Barcelona\u03b2eta Brain Research Center (BBRC)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen M.","family":"Colceriu","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Global Health (ISGlobal)  Barcelona Spain"},{"name":"University of Pompeu Fabra (UPF)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahnaz","family":"Shekari","sequence":"additional","affiliation":[{"name":"Pasqual Maragall Foundation Barcelona\u03b2eta Brain Research Center (BBRC)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muge","family":"Akinci","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Global Health (ISGlobal)  Barcelona Spain"},{"name":"University of Pompeu Fabra (UPF)  Barcelona Spain"},{"name":"Pasqual Maragall Foundation Barcelona\u03b2eta Brain Research Center (BBRC)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Su\u00e1rez\u2010Calvet","sequence":"additional","affiliation":[{"name":"Pasqual Maragall Foundation Barcelona\u03b2eta Brain Research Center (BBRC)  Barcelona Spain"},{"name":"Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Servei de Neurologia Hospital del Mar  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriol","family":"Grau\u2010Rivera","sequence":"additional","affiliation":[{"name":"Pasqual Maragall Foundation Barcelona\u03b2eta Brain Research Center (BBRC)  Barcelona 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eider M.","family":"Arenaza\u2010Urquijo","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Global Health (ISGlobal)  Barcelona Spain"},{"name":"Pasqual Maragall Foundation Barcelona\u03b2eta Brain Research Center (BBRC)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the ALFA 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