{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:00:31Z","timestamp":1790834431482,"version":"4.1.0"},"reference-count":83,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006087","name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","award":["PAPIIT\u2010UNAM IN217824"],"award-info":[{"award-number":["PAPIIT\u2010UNAM IN217824"]}],"id":[{"id":"10.13039\/501100006087","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ecology and Evolution"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Long\u2010term laboratory propagation can be associated with phenotypic and transcriptional differences in model organisms, but comparisons with recently isolated strains and earlier laboratory lineages remain limited. Here, we compared a recently isolated\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    <\/jats:styled-content>\n                    strain from Mexico City (VJV2) with the contemporary N2 Bristol strain. To contextualize laboratory propagation history, we also included the N2 Ancestral strain, a cryopreserved lineage from 1969 derived from early laboratory stocks. Phenotypic assays showed that, under standard laboratory conditions, the VJV2 strain exhibited reduced lifespan and fertility but increased survival following\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    <\/jats:styled-content>\n                    exposure, whereas the Ancestral strain showed higher oxidative stress tolerance but reduced thermotolerance. RNA\u2010seq analyses showed that transcriptomic profiles of the VJV2 and Ancestral strains were more similar to each other than to the contemporary N2 Bristol strain, suggesting expression differences associated with strain history and laboratory propagation. Differential gene expression analyses identified strain\u2010specific expression patterns involving stress\u2010, immune\u2010, and collagen\u2010related genes. Under acute heat stress, only a small set of canonical heat shock genes was commonly upregulated across the three strains, whereas the VJV2, Ancestral, and contemporary N2 Bristol strains exhibited distinct strain\u2010specific expression patterns. Together, these findings provide a comparative phenotypic and transcriptomic characterization of three\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C.\u2009elegans<\/jats:italic>\n                    <\/jats:styled-content>\n                    strains with distinct laboratory histories and highlight the importance of strain background when interpreting experimental outcomes.\n                  <\/jats:p>","DOI":"10.1002\/ece3.74378","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:33:02Z","timestamp":1790832782000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Life\u2010History, Stress\u2010Resistance, and Transcriptomic Variation Among a Mexican\n                    <i>Caenorhabditis elegans<\/i>\n                    Isolate and Contemporary and Ancestral\n                    <scp>N2<\/scp>\n                    Lineages"],"prefix":"10.1002","volume":"16","author":[{"given":"Jaqueline","family":"Hersch\u2010Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Desarrollo, Instituto de Fisiolog\u00eda Celular (IFC) Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM)  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nallely","family":"Cano\u2010Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Desarrollo, Instituto de Fisiolog\u00eda Celular (IFC) Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM)  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Zurita\u2010Le\u00f3n","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Desarrollo, Instituto de Fisiolog\u00eda Celular (IFC) Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM)  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Pinta\u2010Castro","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Desarrollo, Instituto de Fisiolog\u00eda Celular (IFC) Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM)  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maribel","family":"Soto\u2010Nava","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Enfermedades Infecciosas (CIENI) Instituto Nacional de Enfermedades Respiratorias (INER)  Mexico City M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Avila\u2010Rios","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Enfermedades Infecciosas (CIENI) Instituto Nacional de Enfermedades Respiratorias (INER)  Mexico City M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6157-1358","authenticated-orcid":false,"given":"Victor Julian","family":"Valdes","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Desarrollo, Instituto de Fisiolog\u00eda Celular (IFC) Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM)  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/35076538","article-title":"The Natural History of \n                     Caenorhabditis elegans\n                   Research","volume":"2","author":"Ankeny R. A.","year":"2001","journal-title":"Nature Reviews. Genetics"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene Ontology: Tool for the Unification of Biology. The Gene Ontology Consortium","volume":"25","author":"Ashburner M.","year":"2000","journal-title":"Nature Genetics"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1474-9726.2005.00168.x","article-title":"Lifespan and Stress Resistance of \n                     Caenorhabditis elegans\n                   Are Increased by Expression of Glutathione Transferases Capable of Metabolizing the Lipid Peroxidation Product 4\u2010Hydroxynonenal","volume":"4","author":"Ayyadevara S.","year":"2005","journal-title":"Aging Cell"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004583","article-title":"A Wild \n                     C. elegans\n                   Strain Has Enhanced Epithelial Immunity to a Natural Microsporidian Parasite","volume":"11","author":"Balla K. M.","year":"2015","journal-title":"PLoS Pathogens"},{"issue":"3","key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0092-8674(93)80053-H","article-title":"Odorant\u2010Selective Genes and Neurons Mediate Olfaction in \n                     C. elegans","volume":"74","author":"Bargmann C. I.","year":"1993","journal-title":"Cell"},{"key":"e_1_2_10_7_1","first-page":"1","article-title":"Natural Variation and Population Genetics of \n                     Caenorhabditis elegans","volume":"1","author":"Barri\u00e8re A.","year":"2005","journal-title":"WormBook"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1895\/wormbook.1.115.2","article-title":"Isolation of C. elegans and Related Nematodes","volume":"2","author":"Barri\u00e8re A.","year":"2014","journal-title":"WormBook"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","unstructured":"Bell A. D. F.Valencia andA. B.Paaby.2025.\u201cThe Regulatory Architecture of Gene Expression Variation inCaenorhabditis elegansRevealed by Multi\u2010Strain Allele\u2010Specific Analysis.\u201dbioRxiv: The Preprint Server for Biology.https:\/\/doi.org\/10.1101\/2024.10.15.618466.","DOI":"10.1093\/genetics\/iyaf110"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1038\/emboj.2011.193","article-title":"Sgf29 Binds Histone H3K4me2\/3 and Is Required for SAGA Complex Recruitment and Histone H3 Acetylation","volume":"30","author":"Bian C.","year":"2011","journal-title":"EMBO Journal"},{"key":"e_1_2_10_11_1","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adc9851","article-title":"Stimulation of RAS\u2010Dependent ROS Signaling Extends Longevity by Modulating a Developmental Program of Global Gene Expression","volume":"8","author":"Branicky R.","year":"2022","journal-title":"Science Advances"},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The Genetics of \n                     Caenorhabditis elegans","volume":"77","author":"Brenner S.","year":"1974","journal-title":"Genetics"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/s12864-016-2837-5","article-title":"The Genome\u2010Wide Role of HSF\u20101 in the Regulation of Gene Expression in \n                     Caenorhabditis elegans","volume":"17","author":"Brunquell J.","year":"2016","journal-title":"BMC Genomics"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1096\/fj.08-108522","article-title":"Anabolic Function of Phenylalanine Hydroxylase in \n                     Caenorhabditis elegans","volume":"22","author":"Calvo A. C.","year":"2008","journal-title":"FASEB Journal"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","DOI":"10.1093\/genetics\/iyad191","article-title":"Diversification of Small RNA Pathways Underlies Germline RNA Interference Incompetence in Wild \n                     Caenorhabditis elegans\n                   Strains","volume":"226","author":"Chou H. T.","year":"2024","journal-title":"Genetics"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"D650","DOI":"10.1093\/nar\/gkw893","article-title":"CeNDR, the \n                     Caenorhabditis elegans\n                   Natural Diversity Resource","volume":"45","author":"Cook D. E.","year":"2017","journal-title":"Nucleic Acids Research"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1534\/genetics.115.176099","article-title":"A Transparent Window Into Biology: A Primer on \n                     Caenorhabditis elegans","volume":"200","author":"Corsi A. K.","year":"2015","journal-title":"Genetics"},{"key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"D850","DOI":"10.1093\/nar\/gkad887","article-title":"CaeNDR, the Caenorhabditis Natural Diversity Resource","volume":"52","author":"Crombie T. A.","year":"2024","journal-title":"Nucleic Acids Research"},{"key":"e_1_2_10_19_1","first-page":"2201","article-title":"Inhibition of the Oxidative Stress Response by Heat Stress in \n                     Caenorhabditis elegans","volume":"219","author":"Crombie T. A.","year":"2016","journal-title":"Journal of Experimental Biology"},{"key":"e_1_2_10_20_1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/molbev\/msh267","article-title":"Sexual and Temporal Dynamics of Molecular Evolution in \n                     Caenorhabditis elegans\n                   Development","volume":"22","author":"Cutter A. D.","year":"2005","journal-title":"Molecular Biology and Evolution"},{"key":"e_1_2_10_21_1","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0092-8674(00)81609-8","article-title":"Natural Variation in a Neuropeptide Y Receptor Homolog Modifies Social Behavior and Food Response in \n                     C. elegans","volume":"94","author":"Bono M.","year":"1998","journal-title":"Cell"},{"key":"e_1_2_10_22_1","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nature02697","article-title":"High Mutation Rate and Predominance of Insertions in the \n                     Caenorhabditis elegans\n                   Nuclear Genome","volume":"430","author":"Denver D. R.","year":"2004","journal-title":"Nature"},{"key":"e_1_2_10_23_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001230","article-title":"Role of Pleiotropy in the Evolution of a Cryptic Developmental Variation in \n                     Caenorhabditis elegans","volume":"10","author":"Duveau F.","year":"2012","journal-title":"PLoS Biology"},{"key":"e_1_2_10_24_1","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0092-8674(86)90004-8","article-title":"Genetic Control of Programmed Cell Death in the Nematode \n                     C. elegans","volume":"44","author":"Ellis H. M.","year":"1986","journal-title":"Cell"},{"key":"e_1_2_10_25_1","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2164-12-510","article-title":"A Fitness Assay for Comparing RNAi Effects Across Multiple \n                     Caenorhabditis elegans\n                   Genotypes","volume":"12","author":"Elvin M.","year":"2011","journal-title":"BMC Genomics"},{"key":"e_1_2_10_26_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082473","article-title":"Molecular Strategies of the \n                     Caenorhabditis elegans\n                   Dauer Larva to Survive Extreme Desiccation","volume":"8","author":"Erkut C.","year":"2013","journal-title":"PLoS One"},{"key":"e_1_2_10_27_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000175","article-title":"Pseudomonas aeruginosa\n                   Suppresses Host Immunity by Activating the DAF\u20102 Insulin\u2010Like Signaling Pathway in \n                     Caenorhabditis elegans","volume":"4","author":"Evans E. A.","year":"2008","journal-title":"PLoS Pathogens"},{"key":"e_1_2_10_28_1","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2017.02267","article-title":"A Marine Actinomycete Rescues \n                     Caenorhabditis elegans\n                   From \n                     Pseudomonas aeruginosa\n                   Infection Through Restitution of Lysozyme 7","volume":"8","author":"Fatin S. N.","year":"2017","journal-title":"Frontiers in Microbiology"},{"key":"e_1_2_10_29_1","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/35888","article-title":"Potent and Specific Genetic Interference by Double\u2010Stranded RNA in \n                     Caenorhabditis elegans","volume":"391","author":"Fire A.","year":"1998","journal-title":"Nature"},{"key":"e_1_2_10_30_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1126\/science.1258857","article-title":"Lysosomal Signaling Molecules Regulate Longevity in \n                     Caenorhabditis elegans","volume":"347","author":"Folick A.","year":"2015","journal-title":"Science"},{"key":"e_1_2_10_31_1","doi-asserted-by":"crossref","DOI":"10.1093\/genetics\/iyad031","article-title":"The Gene Ontology Knowledgebase in 2023","volume":"224","author":"Gene Ontology Consortium","year":"2023","journal-title":"Genetics"},{"key":"e_1_2_10_32_1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature02714","article-title":"Oxygen Sensation and Social Feeding Mediated by a \n                     C. elegans\n                   Guanylate Cyclase Homologue","volume":"430","author":"Gray J. M.","year":"2004","journal-title":"Nature"},{"key":"e_1_2_10_33_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003466","article-title":"Identification of a Tissue\u2010Selective Heat Shock Response Regulatory Network","volume":"9","author":"Guisbert E.","year":"2013","journal-title":"PLoS Genetics"},{"key":"e_1_2_10_34_1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/sj.hdy.6800929","article-title":"Environmental Influence on the Genetic Correlations Between Life\u2010History Traits in \n                     Caenorhabditis elegans","volume":"98","author":"Gutteling E. W.","year":"2007","journal-title":"Heredity"},{"key":"e_1_2_10_35_1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1534\/genetics.119.302919","article-title":"WormCat: An Online Tool for Annotation and Visualization of \n                     Caenorhabditis elegans\n                   Genome\u2010Scale Data","volume":"214","author":"Holdorf A. D.","year":"2020","journal-title":"Genetics"},{"key":"e_1_2_10_36_1","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1093\/molbev\/msy132","article-title":"Duplication of Hsp\u2010110 Is Implicated in Differential Success of Globodera Species Under Climate Change","volume":"35","author":"Jones L. M.","year":"2018","journal-title":"Molecular Biology and Evolution"},{"key":"e_1_2_10_37_1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12915-019-0725-6","article-title":"Transcriptome Resilience Predicts Thermotolerance in \n                     Caenorhabditis elegans","volume":"17","author":"Jovic K.","year":"2019","journal-title":"BMC Biology"},{"key":"e_1_2_10_38_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0189445","article-title":"Temporal Dynamics of Gene Expression in Heat\u2010Stressed \n                     Caenorhabditis elegans","volume":"12","author":"Jovic K.","year":"2017","journal-title":"PLoS One"},{"key":"e_1_2_10_39_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S1046-2023(03)00050-1","article-title":"Genome\u2010Wide RNAi Screening in \n                     Caenorhabditis elegans","volume":"30","author":"Kamath R. S.","year":"2003","journal-title":"Methods"},{"key":"e_1_2_10_40_1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/366461a0","article-title":"A \n                     C. elegans\n                   Mutant That Lives Twice as Long as Wild Type","volume":"366","author":"Kenyon C.","year":"1993","journal-title":"Nature"},{"key":"e_1_2_10_41_1","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/emboj.2009.387","article-title":"SLR\u20102 and JMJC\u20101 Regulate an Evolutionarily Conserved Stress\u2010Response Network","volume":"29","author":"Kirienko N. V.","year":"2010","journal-title":"EMBO Journal"},{"key":"e_1_2_10_42_1","doi-asserted-by":"crossref","first-page":"3784","DOI":"10.1073\/pnas.1815656116","article-title":"Rhizobium Induces DNA Damage in \n                     Caenorhabditis elegans\n                   Intestinal Cells","volume":"116","author":"Kniazeva M.","year":"2019","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_10_43_1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/s12864-022-08455-2","article-title":"Wild\u2010Type \n                     Caenorhabditis elegans\n                   Isolates Exhibit Distinct Gene Expression Profiles in Response to Microbial Infection","volume":"23","author":"Lansdon P.","year":"2022","journal-title":"BMC Genomics"},{"key":"e_1_2_10_44_1","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.cub.2011.07.042","article-title":"Autophagy and Lipid Metabolism Coordinately Modulate Life Span in Germline\u2010Less \n                     C. elegans","volume":"21","author":"Lapierre L. R.","year":"2011","journal-title":"Current Biology"},{"key":"e_1_2_10_45_1","doi-asserted-by":"crossref","DOI":"10.2478\/jofnem-2022-0010","article-title":"Reproductive Span of \n                     Caenorhabditis elegans\n                   Is Extended by Microbacterium sp","volume":"54","author":"Le T. S.","year":"2022","journal-title":"Journal of Nematology"},{"key":"e_1_2_10_46_1","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","article-title":"The \n                     C. elegans\n                   Heterochronic Gene Lin\u20104 Encodes Small RNAs With Antisense Complementarity to Lin\u201014","volume":"75","author":"Lee R. C.","year":"1993","journal-title":"Cell"},{"key":"e_1_2_10_47_1","doi-asserted-by":"crossref","first-page":"986","DOI":"10.18632\/aging.100960","article-title":"Inverse Correlation Between Longevity and Developmental Rate Among Wild \n                     C. elegans\n                   Strains","volume":"8","author":"Lee Y.","year":"2016","journal-title":"Aging"},{"key":"e_1_2_10_48_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2024.103070","article-title":"Protocol for Survival Assay of \n                     Caenorhabditis elegans\n                   to \n                     Pseudomonas aeruginosa\n                   PA14 Infection","volume":"5","author":"Liu J.","year":"2024","journal-title":"STAR Protocols"},{"key":"e_1_2_10_49_1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.cell.2013.02.049","article-title":"Diet\u2010Induced Developmental Acceleration Independent of TOR and Insulin in \n                     C. elegans","volume":"153","author":"MacNeil L. T.","year":"2013","journal-title":"Cell"},{"key":"e_1_2_10_50_1","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1534\/g3.117.039057","article-title":"Natural Genetic Variation in the \n                     Caenorhabditis elegans\n                   Response to \n                     Pseudomonas aeruginosa","volume":"7","author":"Martin N.","year":"2017","journal-title":"G3: Genes, Genomes, Genetics"},{"key":"e_1_2_10_51_1","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/895236","article-title":"Revelations From the Nematode \n                     Caenorhabditis elegans\n                   on the Complex Interplay of Metal Toxicological Mechanisms","volume":"2011","author":"Martinez\u2010Finley E. J.","year":"2011","journal-title":"Journal of Toxicology"},{"key":"e_1_2_10_52_1","doi-asserted-by":"crossref","DOI":"10.3389\/ffunb.2022.837605","article-title":"Basidiomycota Fungi and ROS: Genomic Perspective on Key Enzymes Involved in Generation and Mitigation of Reactive Oxygen Species","volume":"3","author":"Mattila H.","year":"2022","journal-title":"Frontiers in Fungal Biology"},{"key":"e_1_2_10_53_1","first-page":"463","article-title":"Modes et Formes de Reproduction des Nematodes","volume":"8","author":"Maupas E.","year":"1900","journal-title":"Archives de Zoologie Exp\u00e9rimentale et G\u00e9n\u00e9rale"},{"key":"e_1_2_10_54_1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1534\/genetics.120.303125","article-title":"Cuticle Collagen Expression Is Regulated in Response to Environmental Stimuli by the GATA Transcription Factor ELT\u20103 in \n                     Caenorhabditis elegans","volume":"215","author":"Mesbahi H.","year":"2020","journal-title":"Genetics"},{"key":"e_1_2_10_55_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011730","article-title":"Transcriptional Suppression of Sphingolipid Catabolism Controls Pathogen Resistance in \n                     C. elegans","volume":"19","author":"Nasrallah M. A.","year":"2023","journal-title":"PLoS Pathogens"},{"key":"e_1_2_10_56_1","first-page":"1","article-title":"History of Research on C. elegans and Other Free\u2010Living Nematodes as Model Organisms","volume":"7","author":"Nigon V. M.","year":"2017","journal-title":"WormBook"},{"key":"e_1_2_10_57_1","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1534\/g3.120.401336","article-title":"The Ancestral \n                     Caenorhabditis elegans\n                   Cuticle Suppresses Rol\u20101","volume":"10","author":"Noble L. M.","year":"2020","journal-title":"G3: Genes, Genomes, Genetics"},{"key":"e_1_2_10_58_1","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1534\/g3.120.401316","article-title":"The SEM\u20104 Transcription Factor Is Required for Regulation of the Oxidative Stress Response in \n                     Caenorhabditis elegans","volume":"10","author":"Rafikova A.","year":"2020","journal-title":"G3: Genes, Genomes, Genetics"},{"key":"e_1_2_10_59_1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1126\/science.1166527","article-title":"A Polymorphism in Npr\u20101 Is a Behavioral Determinant of Pathogen Susceptibility in \n                     C. elegans","volume":"323","author":"Reddy K. C.","year":"2009","journal-title":"Science"},{"key":"e_1_2_10_60_1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1126\/science.1114209","article-title":"An Interneuronal Chemoreceptor Required for Olfactory Imprinting in \n                     C. elegans","volume":"309","author":"Remy J. J.","year":"2005","journal-title":"Science"},{"key":"e_1_2_10_61_1","doi-asserted-by":"crossref","first-page":"3750","DOI":"10.1038\/emboj.2010.251","article-title":"The WD40\u2010Repeat Protein Han11 Functions as a Scaffold Protein to Control HIPK2 and MEKK1 Kinase Functions","volume":"29","author":"Ritterhoff S.","year":"2010","journal-title":"EMBO Journal"},{"key":"e_1_2_10_62_1","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1126\/science.1194208","article-title":"Selection at Linked Sites Shapes Heritable Phenotypic Variation in \n                     C. elegans","volume":"330","author":"Rockman M. V.","year":"2010","journal-title":"Science"},{"key":"e_1_2_10_63_1","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.56186","article-title":"Caenorhabditis elegans\n                   Processes Sensory Information to Choose Between Freeloading and Self\u2010Defense Strategies","volume":"9","author":"Schiffer J. A.","year":"2020","journal-title":"eLife"},{"key":"e_1_2_10_64_1","doi-asserted-by":"crossref","first-page":"9829","DOI":"10.1093\/nar\/gkz693","article-title":"Remodeling of the \n                     Caenorhabditis elegans\n                   Non\u2010Coding RNA Transcriptome by Heat Shock","volume":"47","author":"Schreiner W. P.","year":"2019","journal-title":"Nucleic Acids Research"},{"key":"e_1_2_10_65_1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1017\/S003118200300461X","article-title":"Natural Variation in the Response of \n                     Caenorhabditis elegans\n                   Towards \n                     Bacillus thuringiensis","volume":"128","author":"Schulenburg H.","year":"2004","journal-title":"Parasitology"},{"key":"e_1_2_10_66_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12864-017-3899-8","article-title":"Contribution of Trans Regulatory eQTL to Cryptic Genetic Variation in \n                     C. elegans","volume":"18","author":"Snoek B. L.","year":"2017","journal-title":"BMC Genomics"},{"key":"e_1_2_10_67_1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.tig.2015.02.009","article-title":"The Laboratory Domestication of \n                     Caenorhabditis elegans","volume":"31","author":"Sterken M. G.","year":"2015","journal-title":"Trends in Genetics"},{"key":"e_1_2_10_68_1","doi-asserted-by":"crossref","DOI":"10.1093\/genetics\/iyae050","article-title":"WormBase 2024: Status and Transitioning to Alliance Infrastructure","volume":"227","author":"Sternberg P. W.","year":"2024","journal-title":"Genetics"},{"key":"e_1_2_10_69_1","first-page":"1","article-title":"Maintenance of \n                     C. elegans","volume":"11","author":"Stiernagle T.","year":"2006","journal-title":"WormBook"},{"key":"e_1_2_10_70_1","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-020-01379-1","article-title":"Bacterial Diets Differentially Alter Lifespan and Healthspan Trajectories in \n                     C. elegans","volume":"3","author":"Stuhr N. L.","year":"2020","journal-title":"Communications Biology"},{"key":"e_1_2_10_71_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.mbplus.2018.11.001","article-title":"The In\u2010Silico Characterization of the \n                     Caenorhabditis elegans\n                   Matrisome and Proposal of a Novel Collagen Classification","volume":"1","author":"Teuscher A. C.","year":"2019","journal-title":"Matrix Biology Plus"},{"key":"e_1_2_10_72_1","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1111\/acel.12627","article-title":"The SKN\u20101\/Nrf2 Transcription Factor Can Protect Against Oxidative Stress and Increase Lifespan in \n                     C. elegans\n                   by Distinct Mechanisms","volume":"16","author":"Tullet J. M. A.","year":"2017","journal-title":"Aging Cell"},{"key":"e_1_2_10_73_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2021.111622","article-title":"Explaining Inter\u2010Lab Variance in \n                     C. elegans\n                   N2 Lifespan: Making a Case for Standardized Reporting to Enhance Reproducibility","volume":"156","author":"Urban N. D.","year":"2021","journal-title":"Experimental Gerontology"},{"key":"e_1_2_10_74_1","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1101\/gad.241125.114","article-title":"Organismal Proteostasis: Role of Cell\u2010Nonautonomous Regulation and Transcellular Chaperone Signaling","volume":"28","author":"Oosten\u2010Hawle P.","year":"2014","journal-title":"Genes & Development"},{"key":"e_1_2_10_75_1","doi-asserted-by":"crossref","first-page":"5785","DOI":"10.1073\/pnas.1116158109","article-title":"Superoxide dismutase is dispensable for normal animal lifespan","volume":"109","author":"Van Raamsdonk J. M.","year":"2012","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_10_76_1","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1134\/S0006297914070074","article-title":"Caenorhabditis elegans\n                   Eyes Absent Ortholog EYA\u20101 Is Required for Stress Resistance","volume":"79","author":"Wang B. Y.","year":"2014","journal-title":"Biochemistry (Mosc)"},{"key":"e_1_2_10_77_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013922","article-title":"Whole Genome Sequencing Highlights Genetic Changes Associated With Laboratory Domestication of \n                     C. elegans","volume":"5","author":"Weber K. P.","year":"2010","journal-title":"PLoS One"},{"key":"e_1_2_10_78_1","first-page":"1","article-title":"The Structure of the Nervous System of the Nematode \n                     Caenorhabditis elegans","volume":"314","author":"White J. G.","year":"1986","journal-title":"Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences"},{"key":"e_1_2_10_79_1","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0092-8674(93)90530-4","article-title":"Posttranscriptional Regulation of the Heterochronic Gene Lin\u201014 by Lin\u20104 Mediates Temporal Pattern Formation in \n                     C. elegans","volume":"75","author":"Wightman B.","year":"1993","journal-title":"Cell"},{"key":"e_1_2_10_80_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-39882-8","article-title":"Reprogramming of the Transcriptome After Heat Stress Mediates Heat Hormesis in \n                     Caenorhabditis elegans","volume":"14","author":"Xu F.","year":"2023","journal-title":"Nature Communications"},{"key":"e_1_2_10_81_1","doi-asserted-by":"crossref","DOI":"10.1093\/g3journal\/jkab168","article-title":"Natural Variation in Fecundity Is Correlated With Species\u2010Wide Levels of Divergence in \n                     Caenorhabditis elegans","volume":"11","author":"Zhang G.","year":"2021","journal-title":"G3: Genes, Genomes, Genetics"},{"key":"e_1_2_10_82_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-31208-4","article-title":"The Impact of Species\u2010Wide Gene Expression Variation on \n                     Caenorhabditis elegans\n                   Complex Traits","volume":"13","author":"Zhang G.","year":"2022","journal-title":"Nature Communications"},{"key":"e_1_2_10_83_1","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1091\/mbc.12.7.2011","article-title":"RME\u20108, a Conserved J\u2010Domain Protein, Is Required for Endocytosis in \n                     Caenorhabditis elegans","volume":"12","author":"Zhang Y.","year":"2001","journal-title":"Molecular Biology of the Cell"},{"key":"e_1_2_10_84_1","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.38675","article-title":"Changes to Social Feeding Behaviors Are Not Sufficient for Fitness Gains of the \n                     Caenorhabditis elegans\n                   N2 Reference Strain","volume":"7","author":"Zhao Y.","year":"2018","journal-title":"eLife"}],"container-title":["Ecology and Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ece3.74378","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ece3.74378","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ece3.74378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:33:14Z","timestamp":1790832794000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ece3.74378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":83,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/ece3.74378"],"URL":"https:\/\/doi.org\/10.1002\/ece3.74378","archive":["Portico"],"relation":{},"ISSN":["2045-7758","2045-7758"],"issn-type":[{"value":"2045-7758","type":"print"},{"value":"2045-7758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"assertion":[{"value":"2026-05-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e74378"}}