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Using <jats:sup>125<\/jats:sup>I\u2010labeled C1 and a rat monoclonal antibody specific for the class I antigen, it has been found that the rate of activation is primarily dependent on antibody density on the cell surface and not on antigen or C1 density. This finding supports the suggestion that direct contact between the Clr<jats:sub>2<\/jats:sub>Cls<jats:sub>2<\/jats:sub>subcomponent of C1 and antibody may be required for potentiation of C1 activation.<\/jats:p>","DOI":"10.1002\/eji.1830151003","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T21:34:00Z","timestamp":1172698440000},"page":"976-980","source":"Crossref","is-referenced-by-count":18,"title":["Antibody density on rat red cells determines the rate of activation of the complement component Cl"],"prefix":"10.1002","volume":"15","author":[{"given":"Nevin C.","family":"Hughes\u2010Jones","sequence":"first","affiliation":[]},{"given":"Barbara D.","family":"Gorick","sequence":"additional","affiliation":[]},{"given":"Jonathan C.","family":"Howard","sequence":"additional","affiliation":[]},{"given":"Arnold","family":"Feinstein","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.116.2.504"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(82)90321-2"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(82)90370-4"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(83)90105-0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.4049\/jimmunol.132.1.283","volume":"132","author":"Ziccardi R. 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