{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T20:39:09Z","timestamp":1773952749611,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,6,22]],"date-time":"2006-06-22T00:00:00Z","timestamp":1150934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It is generally accepted in immunology that while T and B cells collaborate for the production of antibodies in response to protein antigens, T cells develop and function in the absence of B cells. However, B cell\u2010deficient subjects and mice have unexplained cellular immune defects. Here, we examined the contribution of B cells\/Ig to the generation of diversity and function of T cells. Mice lacking B cells and Ig (JH<jats:sup>\u2013\/\u2013<\/jats:sup>) or having oligoclonal B cells (QM) had a profoundly contracted T cell receptor (TCR) V\u03b2 repertoire: 0.08 and 1.3% of wild type, respectively. Rejection of H\u2010Y\u2010incompatible skin grafts in QM and JH<jats:sup>\u2013\/\u2013<\/jats:sup> mice was significantly delayed (median, 43 and 22\u2004days, respectively) compared to wild\u2010type mice (median, 16\u2004days). Furthermore, reduction of the TCR V\u03b2 diversity by thymectomy in wild\u2010type mice significantly increased survival of H\u2010Y\u2010incompatible skin grafts, and reconstitution of the T cell diversity in QM mice with Ig Fab fragments significantly decreased survival of the skin grafts. These results indicate that B cells and\/or Ig \"help\" T cells through the generation and maintenance of T cell diversity, improving T cell function. Our results may have important implications for therapy and immune reconstitution in the context of AIDS, cancer, autoimmunity and post\u2010myeloablative treatments.<\/jats:p>","DOI":"10.1002\/eji.200635908","type":"journal-article","created":{"date-parts":[[2006,6,22]],"date-time":"2006-06-22T11:05:48Z","timestamp":1150974348000},"page":"1718-1728","source":"Crossref","is-referenced-by-count":16,"title":["Immunoglobulin promotes the diversity and the function of T cells"],"prefix":"10.1002","volume":"36","author":[{"given":"Cristina","family":"Jo\u00e3o","sequence":"first","affiliation":[]},{"given":"Brenda\u2004M.","family":"Ogle","sequence":"additional","affiliation":[]},{"given":"Susan","family":"Geyer","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,6,30]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/194146b0"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/205143a0"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1962.0048"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/2081332a0"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-122-31353"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.1.46-53.2000"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"6002","DOI":"10.1128\/IAI.67.11.6002-6007.1999","article-title":"Importance of B cells, but not specific antibodies, in primary and secondary protective immunity to the intracellular bacterium Francisella tularensis live vaccine strain.","volume":"67","author":"Elkins K. 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