{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T17:35:53Z","timestamp":1775151353596,"version":"3.50.1"},"reference-count":58,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,11,14]],"date-time":"2007-11-14T00:00:00Z","timestamp":1194998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>HIV\u20102 is associated with an attenuated form of HIV disease. We investigate here the immunosuppressive effects of the HIV\u20102 envelope protein, gp105. We found that gp105 suppresses activation of T cells through a monocyte\u2010mediated mechanism. Suppression of T cell activation by gp105 depends on contact between monocytes and T cells, but not on CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup> T cells. The TLR4 pathway is likely involved, since gp105 activates TLR4 signaling and induces TNF\u2010\u03b1 production by monocytes. Immunosuppression is viewed as the main pathophysiologic consequence of infection by HIV. However, the main immunologic defect caused by HIV, depletion of T cells, requires T cell activation. Our findings are consistent with a new concept that HIV\u20102 envelope proteins act on monocytes to suppress T cell activation and that this property may contribute to the benign course of HIV\u20102. We hypothesize that the HIV\u20102 envelope immunosuppressive properties limit bursts of T cell activation, thus reducing viremia and contributing to the slow rate of disease progression that characterizes HIV\u20102 disease.<\/jats:p>","DOI":"10.1002\/eji.200737511","type":"journal-article","created":{"date-parts":[[2007,11,14]],"date-time":"2007-11-14T12:23:44Z","timestamp":1195043024000},"page":"3435-3444","source":"Crossref","is-referenced-by-count":17,"title":["Monocyte\u2010mediated T cell suppression by HIV\u20102 envelope proteins"],"prefix":"10.1002","volume":"37","author":[{"given":"Rita","family":"Cavaleiro","sequence":"first","affiliation":[]},{"given":"Gregory\u2004J.","family":"Brunn","sequence":"additional","affiliation":[]},{"given":"Adriana\u2004S.","family":"Albuquerque","sequence":"additional","affiliation":[]},{"given":"Rui\u2004M.\u2004M.","family":"Victorino","sequence":"additional","affiliation":[]},{"given":"Jeffrey\u2004L.","family":"Platt","sequence":"additional","affiliation":[]},{"given":"Ana\u2004E.","family":"Sousa","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2007,11,29]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1128\/mr.60.2.386-406.1996","article-title":"Envelope glycoproteins of human immunodeficiency virus type 1: profound influences on immune functions.","volume":"60","author":"Chirmule N.","year":"1996","journal-title":"Microbiol. Rev."},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/152581602760404630"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.18.9763-9772.2004"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.7.3931"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.2.1107"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-034785"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611353104"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0503206"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511237103"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-199203000-00005"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)04402-9"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7915856"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042560-199712150-00003"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/322804"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-83-6-1253"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0402-319"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.6.3400"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01557-06"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.5.3252"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni0407-329"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.2174\/1570162052773004"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1993.1160"},{"key":"e_1_2_8_23_2","doi-asserted-by":"crossref","first-page":"8918","DOI":"10.1128\/jvi.71.11.8918-8922.1997","article-title":"Human immunodeficiency virus type 2 envelope glycoprotein binds to CD8 as well as to CD4 molecules on human T cells.","volume":"71","author":"Kaneko H.","year":"1997","journal-title":"J. Virol."},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.1994.10.223"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200012010-00007"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2006.00412.x"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.5.3347"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-3211fje"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.1.20"},{"key":"e_1_2_8_30_2","first-page":"904","article-title":"Elevated levels of CD38+ CD8+ T cells in HIV infection add to the prognostic value of low CD4+ T cell levels: results of 6\u2004years of follow\u2010up. The Los Angeles Center, Multicenter AIDS Cohort Study.","volume":"6","author":"Giorgi J. V.","year":"1993","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"e_1_2_8_31_2","doi-asserted-by":"crossref","first-page":"7772","DOI":"10.1128\/JVI.72.10.7772-7784.1998","article-title":"Effect of immune activation on the dynamics of human immunodeficiency virus replication and on the distribution of viral quasispecies.","volume":"72","author":"Ostrowski M. A.","year":"1998","journal-title":"J. Virol."},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200309050-00006"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00060-8"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-09-3333"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.12.1498"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1511"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70656-9"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.4.2095-2101.2003"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.9.4750"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02403.x"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.10.6758"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.01.002"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2004.12.006"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.4.2691"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061496"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.8.4676"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni926"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.10.5921"},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.042355399"},{"key":"e_1_2_8_50_2","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1242\/jcs.115.12.2603","article-title":"Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide\u2010induced cell activation.","volume":"115","author":"Triantafilou M.","year":"2002","journal-title":"J. Cell Sci."},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.12.047"},{"key":"e_1_2_8_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/326662a0"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/339389a0"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.7.4043-4054.2005"},{"key":"e_1_2_8_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.20.9594-9600.2000"},{"key":"e_1_2_8_56_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042413"},{"key":"e_1_2_8_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/13410"},{"key":"e_1_2_8_58_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.16.7826"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.200737511","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.200737511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T09:35:36Z","timestamp":1700040936000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.200737511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,29]]},"references-count":58,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1002\/eji.200737511"],"URL":"https:\/\/doi.org\/10.1002\/eji.200737511","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,29]]}}}