{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:47:20Z","timestamp":1773769640497,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,4,3]],"date-time":"2008-04-03T00:00:00Z","timestamp":1207180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>IL\u201010 is a potent anti\u2010inflammatory cytokine interfering with antigen presentation by inducing the intracellular sequestration of MHC class II (MHC\u2010II) molecules. Here we studied the contribution of membrane\u2010associated RING\u2010CH (MARCH) ubiquitin ligase family members to the IL\u201010\u2010induced down\u2010regulation of MHC\u2010II molecules. We found that MARCH1 and MARCH8 proteins are the most potent family members for the down\u2010regulation of MHC\u2010II surface expression in transfected cells, but only MARCH1 mRNA expression is strongly induced by IL\u201010 in human primary monocytes. We detected mono\u2010 and poly\u2010ubiquitinated forms of MHC\u2010II molecules both in IL\u201010\u2010treated monocytes and in cells transfected with MARCH1. We also show direct interaction between MHC\u2010II and MARCH1 molecules in co\u2010immunoprecipitation assays. Finally, we found that siRNA\u2010mediated knockdown of MARCH1 reverses IL\u201010\u2010induced MHC\u2010II down\u2010regulation in primary monocytes. Thus, the immunosuppressive effect of IL\u201010 on antigen presentation is mediated through induced expression of MARCH1.<\/jats:p>","DOI":"10.1002\/eji.200737902","type":"journal-article","created":{"date-parts":[[2008,4,3]],"date-time":"2008-04-03T08:48:23Z","timestamp":1207212503000},"page":"1225-1230","source":"Crossref","is-referenced-by-count":136,"title":["Interleukin\u201010\u2010induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes"],"prefix":"10.1002","volume":"38","author":[{"given":"Jacques","family":"Thibodeau","sequence":"first","affiliation":[]},{"given":"Marie\u2010Claude","family":"Bourgeois\u2010Daigneault","sequence":"additional","affiliation":[]},{"given":"Gabrielle","family":"Hupp\u00e9","sequence":"additional","affiliation":[]},{"given":"Jessy","family":"Tremblay","sequence":"additional","affiliation":[]},{"given":"Ang\u00e9lique","family":"Aumont","sequence":"additional","affiliation":[]},{"given":"Mathieu","family":"Houde","sequence":"additional","affiliation":[]},{"given":"Eric","family":"Bartee","sequence":"additional","affiliation":[]},{"given":"Alexandre","family":"Brunet","sequence":"additional","affiliation":[]},{"given":"Marie\u2010Elaine","family":"Gauvreau","sequence":"additional","affiliation":[]},{"given":"Aude","family":"de 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