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Therefore, we examined the capacity of murine BM\u2010derived DC to internalize parasites, be activated and produce cytokines upon <jats:italic>in vitro<\/jats:italic> interaction with murine erythrocytes infected with two different strains of rodent malaria parasites (<jats:italic>Plasmodium berghei<\/jats:italic> and <jats:italic>Plasmodium chabaudi chabaudi<\/jats:italic>). We show that the increased expression of MHC class II and co\u2010stimulatory molecules and increased production of cytokines by DC following <jats:italic>Plasmodium<\/jats:italic> infection involves internalization of infected RBC. Such DC activation not only requires direct cell\u2010to\u2010cell contact and internalization of infected RBC by DC but also involves TLR4, TLR9, MyD88 and signaling <jats:italic>via<\/jats:italic> NF\u2010\u03baB; however, TLR involvement in survival to <jats:italic>Plasmodium<\/jats:italic> infection was found to be negligible.<\/jats:p>","DOI":"10.1002\/eji.200838403","type":"journal-article","created":{"date-parts":[[2009,7,7]],"date-time":"2009-07-07T07:04:17Z","timestamp":1246950257000},"page":"1850-1863","source":"Crossref","is-referenced-by-count":25,"title":["The interaction between DC and <i>Plasmodium berghei\/chabaudi<\/i>\u2010infected erythrocytes in mice involves direct cell\u2010to\u2010cell contact, internalization and TLR"],"prefix":"10.1002","volume":"39","author":[{"given":"Elsa","family":"Seixas","sequence":"first","affiliation":[]},{"given":"Jos\u00e9 F.","family":"Moura 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