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In the present report, we investigated in detail the function of CD300e in monocytes and myeloid DC (mDC) freshly isolated from peripheral blood of normal blood donors. Upon engagement by an agonistic mAb, CD300e triggered an intracellular calcium mobilization and superoxide anion O<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-stack-1.gif\" xlink:title=\"urn:x-wiley:00142980:media:EJI200939468:tex2gif-stack-1\"\/> production in monocytes. Activation <jats:italic>via<\/jats:italic> CD300e provided survival signals that prevented monocyte and mDC apoptosis, triggered the production of pro\u2010inflammatory cytokines and upregulated the expression of cell surface co\u2010stimulatory molecules in both cell types. Moreover, CD300e activation of mDC enhanced the alloreactive response of naive T cells. Overall, our data formally support the notion that CD300e functions as an activating receptor capable of regulating the innate immune response in myeloid cells.<\/jats:p>","DOI":"10.1002\/eji.200939468","type":"journal-article","created":{"date-parts":[[2009,12,28]],"date-time":"2009-12-28T15:47:12Z","timestamp":1262015232000},"page":"722-732","source":"Crossref","is-referenced-by-count":45,"title":["Functional analysis of the CD300e receptor in human monocytes and myeloid dendritic cells"],"prefix":"10.1002","volume":"40","author":[{"given":"Tamara","family":"Brckalo","sequence":"first","affiliation":[]},{"given":"Federica","family":"Calzetti","sequence":"additional","affiliation":[]},{"given":"Bego\u00f1a","family":"P\u00e9rez\u2010Cabezas","sequence":"additional","affiliation":[]},{"given":"Francesc E.","family":"Borr\u00e0s","sequence":"additional","affiliation":[]},{"given":"Marco A.","family":"Cassatella","sequence":"additional","affiliation":[]},{"given":"Miguel","family":"L\u00f3pez\u2010Botet","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2010,3,3]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115816"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1106"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00325.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.197"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(03)00039-6"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5489.84"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.20.081501.130710"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81357-4"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2009.02.003"},{"key":"e_1_2_6_11_2","first-page":"55","article-title":"Expression of the CMRF\u201035 antigen, a new member of the immunoglobulin gene superfamily, is differentially regulated on leucocytes","volume":"79","author":"Daish A.","year":"1993","journal-title":"Immunology"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-12-127951"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199910)29:10<3148::AID-IMMU3148>3.0.CO;2-L"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.12.7989"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-2926"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2007.05.006"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425433"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.2.808"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.5.2819"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-04-085787"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.11.6703"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2007.01.018"},{"key":"e_1_2_6_23_2","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.4049\/jimmunol.147.10.3408","article-title":"Differential regulation of human monocyte programmed cell death (apoptosis) by chemotactic factors and pro\u2010inflammatory cytokines","volume":"147","author":"Mangan D. 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