{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T12:35:22Z","timestamp":1771331722967,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,5,25]],"date-time":"2011-05-25T00:00:00Z","timestamp":1306281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>NF\u2010\u03baB1\u2010dependent signaling directs the development of CD4<jats:sup>+<\/jats:sup> Th2 cells during allergic airway inflammation and protective responses to helminth infection. Here, we show that IL\u20104 and IL\u201013 production is NF\u2010\u03baB1\u2010dependent in mouse OVA\u2010specific CD4<jats:sup>+<\/jats:sup> (OTII) T cells responding to alum\u2010precipitated OVA (alumOVA) immunization. More surprisingly, we found that NF\u2010\u03baB1 deficiency in OTII cells also selectively impairs their CXCR5 induction by alumOVA without affecting upregulation of BCL6, IL\u201021, OX40 and CXCR4 mRNA and PD\u20101 protein. This results in functional impairment of follicular helper T cells. Thus, fewer germinal center B cells develop in LN responses to alumOVA in T\u2010cell\u2010deficient mice reconstituted with NF\u2010\u03baB1<jats:sup>\u2212\/\u2212<\/jats:sup> OTII cells as opposed to NF\u2010\u03baB1<jats:sup>+\/+<\/jats:sup> OTII cells, while plasma cell numbers are comparable. Unlike CXCR5 induction in CD4<jats:sup>+<\/jats:sup> T cells, NF\u2010\u03baB1\u2010deficient recirculating follicular B cells are shown to express normal levels of CXCR5. The selective effects of NF\u2010\u03baB1\u2010deficiency on Th2 and follicular helper T cell induction do not appear to be due to altered expression of the Th2\u2010associated transcription factors \u2014 GATA\u20103, c\u2010Maf and Ikaros. Altogether, these results suggest that NF\u2010\u03baB1 regulates the expression of CXCR5 on CD4<jats:sup>+<\/jats:sup> T cells primed in vivo, and thus selectively controls the T\u2010cell\u2010dependent germinal center component of B\u2010cell response to alumOVA.<\/jats:p>","DOI":"10.1002\/eji.201041126","type":"journal-article","created":{"date-parts":[[2011,4,6]],"date-time":"2011-04-06T13:50:54Z","timestamp":1302097854000},"page":"1573-1582","source":"Crossref","is-referenced-by-count":27,"title":["Selective effects of NF\u2010\u03baB1 deficiency in CD4<sup>+<\/sup> T cells on Th2 and TFh induction by alum\u2010precipitated protein vaccines"],"prefix":"10.1002","volume":"41","author":[{"given":"Karine","family":"Serre","sequence":"first","affiliation":[]},{"given":"Elodie","family":"Mohr","sequence":"additional","affiliation":[]},{"given":"C\u00e9cile","family":"B\u00e9n\u00e9zech","sequence":"additional","affiliation":[]},{"given":"Roger","family":"Bird","sequence":"additional","affiliation":[]},{"given":"Mahmood","family":"Khan","sequence":"additional","affiliation":[]},{"given":"Jorge H.","family":"Caama\u00f1o","sequence":"additional","affiliation":[]},{"given":"Adam F.","family":"Cunningham","sequence":"additional","affiliation":[]},{"given":"Ian C. 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