{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T04:30:35Z","timestamp":1774413035628,"version":"3.50.1"},"reference-count":105,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T00:00:00Z","timestamp":1607385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","award":["ALTF 752\u20132018"],"award-info":[{"award-number":["ALTF 752\u20132018"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\u03b3\u03b4 T cells can display a plethora of immune functions, but recent studies have highlighted their importance, in multiple disease models, as sources of the pro\u2010inflammatory cytokines, IL\u201017A (IL\u201017), and IFN\u2010\u03b3. These are produced by distinct murine effector \u03b3\u03b4 T cell subsets that diverge during thymic \u03b3\u03b4 T cell development. Among the multiple roles these subsets play in peripheral tissues, a striking dichotomy has emerged at tumor sites: whereas IFN\u2010\u03b3<jats:sup>+<\/jats:sup> \u03b3\u03b4 T cells inhibit tumor cell growth, IL\u201017<jats:sup>+<\/jats:sup> \u03b3\u03b4 T cells promote tumor progression and metastasis formation. In this review, we discuss the main lines of evidence, mostly from preclinical studies in mouse models, for this functional dichotomy in cancer immunity. We further highlight very recent advances in our understanding how metabolic sources and pathways can impact on the balance between IFN\u2010\u03b3<jats:sup>+<\/jats:sup> and IL\u201017<jats:sup>+<\/jats:sup> \u03b3\u03b4 T cells in the tumor microenvironment, which opens a new exciting avenue to explore toward the application of \u03b3\u03b4 T cells in cancer immunotherapy.<\/jats:p>","DOI":"10.1002\/eji.201948402","type":"journal-article","created":{"date-parts":[[2020,11,14]],"date-time":"2020-11-14T17:00:47Z","timestamp":1605373247000},"page":"17-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Functional and metabolic dichotomy of murine \u03b3\u03b4 T cell subsets in cancer immunity"],"prefix":"10.1002","volume":"51","author":[{"given":"No\u00eblla","family":"Lopes","sequence":"first","affiliation":[{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina Universidade de Lisboa  Lisbon Portugal"}]},{"given":"Bruno","family":"Silva\u2010Santos","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina Universidade de Lisboa  Lisbon Portugal"}]}],"member":"311","published-online":{"date-parts":[[2020,12,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-00452-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201343759"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.01.007"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13032"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1717"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.05.071"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3424"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12918"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3726"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0153-5"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0038-z"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aav4036"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.08.006"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3904"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/322836a0"},{"key":"e_1_2_6_17_1","article-title":"Distinct metabolic programmes established in the thymus control the effector functions of \u03b3\u03b4 T cell subsets in tumour microenvironments","author":"Lopes N.","year":"2020","journal-title":"Nat. Immunol."},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.4618"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.9.6177"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201847379"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-2534"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14282"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.12.040"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1403424111"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1712883114"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002901"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2014.03.014"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200940157"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.03.013"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2017.1347742"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-15-0154"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902574"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1814-0"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-0054"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2004990"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021282"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1063916"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031981"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903767"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.9.6044"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030584"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.04.018"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1556"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.5A0116-053RR"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.3.1338"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-4912"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0804288"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103710"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903454"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00607"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(05)87002-6"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2011.01.001"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-363655"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-08-172296"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13110"},{"key":"e_1_2_6_56_1","first-page":"10","article-title":"In vivo major histocompatibility complex class I (MHCI) expression on MHCIlow tumor cells is regulated by gammadelta T and NK cells during the early steps of tumor growth","volume":"9","author":"Riond J.","year":"2009","journal-title":"Cancer Immun."},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0161-8"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12080"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1211250"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20180660"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1110267"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-011-1111-6"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/593562"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102654"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-015-1700-x"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2016.10.009"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2012.01150.x"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-042617-053019"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1160809"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08155"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08097"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.12.007"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1221740110"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2687"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.11.007"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401558"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.8.4670"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.01.022"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0140-9"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.016"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.016"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.02.024"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aan4631"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002202"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.12.011"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3439"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04719-2"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.11.001"},{"key":"e_1_2_6_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.12.019"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0251-7"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2017.03.011"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-1491"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.09.031"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.10.001"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2012.10.001"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9051140"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7692"},{"key":"e_1_2_6_98_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.21.9543-9553.2005"},{"key":"e_1_2_6_99_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf1292"},{"key":"e_1_2_6_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.08.018"},{"key":"e_1_2_6_101_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20171068"},{"key":"e_1_2_6_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.12.015"},{"key":"e_1_2_6_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2015.04.008"},{"key":"e_1_2_6_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2006.07.002"},{"key":"e_1_2_6_105_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aax9364"},{"key":"e_1_2_6_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30134"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201948402","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/eji.201948402","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.201948402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T16:40:32Z","timestamp":1693672832000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201948402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,8]]},"references-count":105,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/eji.201948402"],"URL":"https:\/\/doi.org\/10.1002\/eji.201948402","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,8]]},"assertion":[{"value":"2020-08-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}