{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T19:40:34Z","timestamp":1774554034727,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000348","name":"Calouste Gulbenkian Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Peptidyl\u2010prolyl cis\u2010trans isomerase C<\/jats:italic>\n                    (\n                    <jats:italic>Ppic<\/jats:italic>\n                    ) is expressed in several bone marrow (BM) hematopoietic progenitors and in T\u2010cell precursors. Since the expression profile of\n                    <jats:italic>Ppic<\/jats:italic>\n                    in the hematoimmune system was suggestive that it could play a role in hematopoiesis and\/or T lymphocyte differentiation, we sought to test that hypothesis in vivo. Specifically, we generated a\n                    <jats:italic>Ppic<\/jats:italic>\n                    \u2010deficient mouse model by targeting the endogenous locus by\n                    <jats:italic>CRISPR\/Cas9<\/jats:italic>\n                    and tested the requirement of\n                    <jats:italic>Ppic<\/jats:italic>\n                    in hematopoiesis. Several immune cell lineages covering BM progenitors, lymphocyte precursors, as well as mature cells at the periphery were analyzed. While most lineages were unaffected, invariant NKT (iNKT) cells were reduced in percentage and absolute cell numbers in the\n                    <jats:italic>Ppic<\/jats:italic>\n                    \u2010deficient thymus. This affected the most mature stages in the thymus, S2 and S3, and the phenotype was maintained at the periphery. Additionally, immature transitional T1 and T2 B lymphocytes were increased in the\n                    <jats:italic>Ppic<\/jats:italic>\n                    \u2010deficient spleen, but the phenotype was lost in mature B lymphocytes. In sum, our data show that\n                    <jats:italic>Ppic<\/jats:italic>\n                    is dispensable for myeloid cells, platelets, erythrocytes, \u03b1\u03b2, and \u03b3\u03b4 T lymphocytes in vivo in the steady state, while being involved in B\u2010 and iNKT cell differentiation.\n                  <\/jats:p>","DOI":"10.1002\/eji.202048924","type":"journal-article","created":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T07:40:06Z","timestamp":1618645206000},"page":"1968-1979","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["<i>Peptidylprolyl isomerase C (Ppic)<\/i>\n                    regulates invariant Natural Killer T cell (iNKT) differentiation in mice"],"prefix":"10.1002","volume":"51","author":[{"given":"Ricardo S.","family":"Paiva","sequence":"first","affiliation":[{"name":"Lymphocyte Development and Leukemogenesis Laboratory Instituto Gulbenkian de Ci\u00eancia, Calouste Gulbenkian Foundation  Oeiras Portugal"}]},{"given":"Camila V.","family":"Ramos","sequence":"additional","affiliation":[{"name":"Lymphocyte Development and Leukemogenesis Laboratory Instituto Gulbenkian de Ci\u00eancia, Calouste Gulbenkian Foundation  Oeiras Portugal"}]},{"given":"Sara R.","family":"Azenha","sequence":"additional","affiliation":[{"name":"Lymphocyte Development and Leukemogenesis Laboratory Instituto Gulbenkian de Ci\u00eancia, Calouste Gulbenkian Foundation  Oeiras Portugal"}]},{"given":"Carolina","family":"Alves","sequence":"additional","affiliation":[{"name":"Lymphocyte Development and Leukemogenesis Laboratory Instituto Gulbenkian de Ci\u00eancia, Calouste Gulbenkian Foundation  Oeiras Portugal"}]},{"given":"Afonso P.","family":"Basto","sequence":"additional","affiliation":[{"name":"CIISA\u2014Centro de Investiga\u00e7\u00e3o Interdisciplinar em Sanidade Animal Faculdade de Medicina Veterin\u00e1ria Universidade de Lisboa  Lisboa Portugal"}]},{"given":"Luis","family":"Graca","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular Faculdade de Medicina Universidade de Lisboa  Lisboa Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8717-9709","authenticated-orcid":false,"given":"Vera C.","family":"Martins","sequence":"additional","affiliation":[{"name":"Lymphocyte Development and Leukemogenesis Laboratory Instituto Gulbenkian de Ci\u00eancia, Calouste Gulbenkian Foundation  Oeiras Portugal"}]}],"member":"311","published-online":{"date-parts":[[2021,5,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90123-G"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.175"},{"key":"e_1_2_10_4_1","first-page":"1247","article-title":"An analysis of the expression of cyclophilin C reveals tissue restriction and an intriguing pattern in the mouse kidney","volume":"144","author":"Friedman J.","year":"1994","journal-title":"Am. 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