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While the transcriptional regulation of Tfh differentiation has been studied in great detail, the impact of micro RNAs (miRNAs) on Tfh development and stability has been harder to address. It was previously shown that a complete deletion of miRNAs biogenesis prevents Tfh differentiation. In this issue of the <jats:italic>European Journal of Immunology<\/jats:italic> [Eur. J. Immunol. 2021. 51: 408\u2010413], Zeitr\u00e4g et\u00a0al. use an inducible gene deletion approach to reveal that miRNAs are also required for the maintenance of Tfh cells induced following viral infection in mice. These results provide new clues to the regulation of GC responses through Tfh and T follicular regulatory cells.<\/jats:p>","DOI":"10.1002\/eji.202049086","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T23:28:57Z","timestamp":1610753337000},"page":"292-295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Micro RNAs in Tfh regulation: Small molecules with a big impact"],"prefix":"10.1002","volume":"51","author":[{"given":"Afonso P.","family":"Basto","sequence":"first","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina Universidade de Lisboa  Lisboa Portugal"},{"name":"CIISA\u2010Centro de Investiga\u00e7\u00e3o Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterin\u00e1ria Universidade de Lisboa  Lisboa Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6935-8500","authenticated-orcid":false,"given":"Luis","family":"Graca","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina Universidade de Lisboa  Lisboa Portugal"}]}],"member":"311","published-online":{"date-parts":[[2021,2,2]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-041015-055605"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.04.011"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3447"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101328"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2425"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2426"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12739"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2019.02.007"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12774"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3494"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2057"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050678"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061692"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2642"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12735"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202048867"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.05.005"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20170457"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15067"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2020.10.009"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12888"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02469"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aan1487"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2648"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.202049086","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/eji.202049086","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.202049086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T17:20:55Z","timestamp":1693675255000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.202049086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1002\/eji.202049086"],"URL":"https:\/\/doi.org\/10.1002\/eji.202049086","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"type":"print","value":"0014-2980"},{"type":"electronic","value":"1521-4141"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"2020-12-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}