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Innate lymphoid cells (ILCs) are likely players, given their role in mucosal protection and tissue homeostasis. We studied ILC subpopulations at two time points in a cohort of patients admitted in the hospital due to SARS\u2010CoV\u20102 infection. COVID\u201019 patients with moderate\/severe respiratory failure featured profound depletion of circulating ILCs at hospital admission, in agreement with overall lymphocyte depletion. However, ILCs recovered in direct correlation with lung function improvement as measured by oxygenation index and in negative association with inflammatory and lung\/endothelial damage markers like RAGE. While both ILC1 and ILC2 expanded, ILC2 showed the most striking phenotype changes, with CCR10 upregulation in strong correlation with these parameters. Overall, CCR10\n                    <jats:sup>+<\/jats:sup>\n                    ILC2 emerge as relevant contributors to SARS\u2010CoV\u20102 pneumonia recovery.\n                  <\/jats:p>","DOI":"10.1002\/eji.202149311","type":"journal-article","created":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T07:39:00Z","timestamp":1632641940000},"page":"3194-3201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["SARS\u2010CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells type 2 expressing CCR10"],"prefix":"10.1002","volume":"51","author":[{"given":"Andr\u00e9 M. 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M.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes Faculdade de Medicina Universidade de Lisboa  Lisboa Portugal"}]},{"given":"Ana E.","family":"Sousa","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes Faculdade de Medicina Universidade de Lisboa  Lisboa Portugal"}]},{"given":"Susana M.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes Faculdade de Medicina Universidade de Lisboa  Lisboa Portugal"},{"name":"Cl\u00ednica Universit\u00e1ria de Medicina Intensiva Faculdade de Medicina Universidade de Lisboa  Lisboa Portugal"},{"name":"Servi\u00e7o de Medicina Intensiva Centro Hospitalar Universit\u00e1rio Lisboa Norte  Lisboa Portugal"}]}],"member":"311","published-online":{"date-parts":[[2021,10,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06192-2"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202008-3212OC"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03252-9"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2020.08.009"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu126"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2017.44"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12547"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3443"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2131"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13679"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00861"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2017-211097"},{"key":"e_1_2_11_14_1","article-title":"Innate lymphoid cells and disease tolerance in SARS\u2010CoV\u20102 infection","author":"Silverstein N. 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