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In this context, metal\u2010organic frameworks (MOFs) are attracting attention because they can act as reservoirs releasing metal ions with antibacterial properties. This action is reminiscent of that proposed for metal\u2010 and metal oxide\u2010nanoparticles but different from the action of antibiotics. These features make MOFs promising candidates for pharmaceutical and biomedical applications. Here, <jats:bold>IRMOF\u20103<\/jats:bold> was modified with 2,5\u2010dimethoxytetrahydrofuran, <jats:italic>N<\/jats:italic>,<jats:italic>N\u2032<\/jats:italic>\u2010disuccinimidyl carbonate, acryloyl chloride, and phthalaldehyde to produce, respectively, <jats:bold>IRMOF\u20103\u2010FU<\/jats:bold>, <jats:bold>IRMOF\u20103\u2010SU<\/jats:bold>, <jats:bold>IRMOF\u20103\u2010AC<\/jats:bold>, <jats:bold>IRMOF\u20103\u2010DL<\/jats:bold> in 38 to 90\u2009% yields. Remarkably, the biological activity of these compounds evaluated against various bacterial and fungal strains is higher than the activity of commercial antibiotics.<\/jats:p>","DOI":"10.1002\/ejic.201801442","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T21:54:45Z","timestamp":1548885285000},"page":"1243-1249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["IRMOF\u20103 Biological Activity Enhancement by Post\u2010Synthetic Modification"],"prefix":"10.1002","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1700-5361","authenticated-orcid":false,"given":"Reda M.","family":"Abdelhameed","sequence":"first","affiliation":[{"name":"Applied Organic Chemistry Department National Research Centre  33 EL Bohouth st. 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