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The presence of the ester group at the 2\u2010position of the benzo[<jats:italic>b<\/jats:italic>]thiophene moiety increases the yields and lowers the heating times relative to the reactions performed with 3\u2010bromobenzo[<jats:italic>b<\/jats:italic>]thiophene. When aminopyridines were used instead of anilines, the ligand and the solvent need to be changed to XANTHPHOS and dioxane in the amination reaction. With 2\u2010aminopyridine a one\u2010pot C\u2212N coupling and intramolecular cyclization involving the nitrogen atom of the pyridine ring occurred, with loss of ethanol, giving an interesting fluorescent tetracyclic heteroaromatic compound. The antimicrobial activity, the minimal inhibitory concentrations (MICs) and the structure\u2010activity relationships (SARs) were evaluated. A selectivity with low MICs was observed against <jats:italic>Bacillus Cereus<\/jats:italic>, and good results were also obtained against <jats:italic>Candida albicans<\/jats:italic>. The acids obtained by hydrolysis of the ester group, as non\u2010proteinogenic \u03b1,\u03b2\u2010unsaturated \u03b2\u2010amino acids, can be incorporated into peptide chains to induce conformational constraints. (\u00a9 Wiley\u2010VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2004)<\/jats:p>","DOI":"10.1002\/ejoc.200400218","type":"journal-article","created":{"date-parts":[[2004,8,17]],"date-time":"2004-08-17T06:31:14Z","timestamp":1092724274000},"page":"3679-3685","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Palladium\u2010Catalysed Amination of Electron\u2010Deficient or Relatively Electron\u2010Rich Benzo[<i>b<\/i>]thienyl Bromides \u2212 Preliminary Studies of Antimicrobial Activity and SARs"],"prefix":"10.1002","volume":"2004","author":[{"given":"Maria\u2010Jo\u00e3o\u00a0R.\u00a0P.","family":"Queiroz","sequence":"first","affiliation":[]},{"given":"Agathe","family":"Begouin","sequence":"additional","affiliation":[]},{"given":"Isabel\u00a0C.\u00a0F.\u00a0R.","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"Gilbert","family":"Kirsch","sequence":"additional","affiliation":[]},{"given":"Ricardo\u00a0C.","family":"Calhelha","sequence":"additional","affiliation":[]},{"given":"Sandra","family":"Barbosa","sequence":"additional","affiliation":[]},{"given":"Let\u00edcia\u00a0M.","family":"Estevinho","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2004,8,17]]},"reference":[{"key":"e_1_2_6_1_2","unstructured":"\u00a0"},{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","unstructured":"E. 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