{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T07:27:08Z","timestamp":1769239628565,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2009,4,30]],"date-time":"2009-04-30T00:00:00Z","timestamp":1241049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Org Chem"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Di(hetero)arylamides have been synthesized in short reaction times by palladium\u2010catalysed multicomponent aminocarbonylation of either electron\u2010deficient or electron\u2010rich heteroaryl halides and <jats:italic>p<\/jats:italic>\u2010iodoanisole with several arylamines bearing either electron\u2010donating or \u2010withdrawing groups and aminopyridines using [Mo(CO)<jats:sub>6<\/jats:sub>] as a solid CO source and conventional heating. Starting from heteroaryl bromides, a palladacycle with <jats:italic>t<\/jats:italic>Bu<jats:sub>3<\/jats:sub>PHBF<jats:sub>4<\/jats:sub> as ligand is required together with DBU as a base in dioxane and a temperature of 125 \u00b0C. From (hetero)aryl iodides, Pd(OAc)<jats:sub>2<\/jats:sub> without a ligand and DBU were used in dioxane at 110 \u00b0C. Under the latter conditions we were able to apply this reaction to deactivated aminopyridines to obtain the corresponding di(hetero)arylamides. We have demonstrated that these reactions can be performed under conventional heating (110\u2013125 \u00b0C) to yield the corresponding di(hetero)arylamides in moderate\u2010to\u2010high yields in short reaction times (from 1\u20133 h) with no need for MW irradiation. A <jats:italic>N<\/jats:italic>\u2010substituted isoindoline\u20101,3\u2010dione from 2\u2010iodobenzoic acid or methyl 2\u2010iodobenzoate and <jats:italic>p<\/jats:italic>\u2010anisidine through a one\u2010step carbonylative cyclization reaction was also obtained. Thus, we have extended the scope of thispalladium\u2010catalysed aminocarbonylation reaction with [Mo(CO)<jats:sub>6<\/jats:sub>] to several (hetero)aryl substrates using conventional heating. (\u00a9 Wiley\u2010VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2009)<\/jats:p>","DOI":"10.1002\/ejoc.200900167","type":"journal-article","created":{"date-parts":[[2009,4,30]],"date-time":"2009-04-30T12:10:25Z","timestamp":1241093425000},"page":"2820-2827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Palladium\u2010Catalysed Multicomponent Aminocarbonylation of Aryl or Heteroaryl Halides with [Mo(CO)<sub>6<\/sub>] and Aryl\u2010 or \u00adHeteroarylamines Using Conventional Heating"],"prefix":"10.1002","volume":"2009","author":[{"given":"Agathe","family":"Begouin","sequence":"first","affiliation":[]},{"given":"Maria\u2010Jo\u00e3o R. 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