{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:15:05Z","timestamp":1762323305553,"version":"build-2065373602"},"reference-count":38,"publisher":"Wiley","issue":"33","license":[{"start":{"date-parts":[[2009,10,7]],"date-time":"2009-10-07T00:00:00Z","timestamp":1254873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Org Chem"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The isolation, identification and total synthesis of two plant\u2010derived inhibitors of the NF\u2010\u03baB signaling pathway from the iso\u2010<jats:italic>seco<\/jats:italic>\u2010tanapartholide family of natural products is described. A key step in the efficient reaction sequence is a late\u2010stage oxidative cleavage reaction that was carried out in the absence of protecting groups to give the natural products directly. A detailed comparison of the synthetic material with samples of the natural products proved informative. Biological studies on synthetic material confirmed that these compounds act late in the NF\u2010\u03baB signaling pathway. (\u00a9 Wiley\u2010VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2009)<\/jats:p>","DOI":"10.1002\/ejoc.200901016","type":"journal-article","created":{"date-parts":[[2009,10,7]],"date-time":"2009-10-07T11:13:12Z","timestamp":1254913992000},"page":"5711-5715","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Iso\u2010<i>seco<\/i>\u2010tanapartholides: Isolation, Synthesis and Biological Evaluation"],"prefix":"10.1002","volume":"2009","author":[{"given":"Edward F.","family":"Makiyi","sequence":"first","affiliation":[]},{"given":"Raquel F. M.","family":"Frade","sequence":"additional","affiliation":[]},{"given":"Tomas","family":"Lebl","sequence":"additional","affiliation":[]},{"given":"Ellis G.","family":"Jaffray","sequence":"additional","affiliation":[]},{"given":"Susan E.","family":"Cobb","sequence":"additional","affiliation":[]},{"given":"Alan L.","family":"Harvey","sequence":"additional","affiliation":[]},{"given":"Alexandra M. Z.","family":"Slawin","sequence":"additional","affiliation":[]},{"given":"Ronald T.","family":"Hay","sequence":"additional","affiliation":[]},{"given":"Nicholas J.","family":"Westwood","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2009,11,3]]},"reference":[{"key":"e_1_2_5_1_2","unstructured":"\u00a0"},{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","unstructured":"R. E. Dolle B. Le Bourdonnec A. J. Goodman G. A. Morales C. J. Thomas W. Zhang J. Comb. 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These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk\/data_request\/cif."},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00915a035"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlac.19565990202"},{"key":"e_1_2_5_31_2","unstructured":"In this reaction a compound tentatively assigned as the C3 oxo derivative of1was formed."},{"key":"e_1_2_5_32_2","unstructured":"[\u03b1]D20(1) = +2.9 (c= 0.8 CHCl3); [\u03b1]D20(2) = \u20136.5 (c= 0.2 CHCl3)."},{"key":"e_1_2_5_33_2","unstructured":"This sample was kindly provided by Professor Todorova. For example see M. Todorova E. Mustakerova E. Tsankova Dokl. Bulg. Akad. 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