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Recent advances in the radiosynthesis of [<jats:sup>18<\/jats:sup>F]FDG (electrophilic vs. nucleophilic radiofluorinations), a PET radiotracer based on glucose and the most widely PET tracer currently in use for cancer and inflammatory disease diagnosis, is considered. The powerful impact of [<jats:sup>18<\/jats:sup>F]FDG in the clinic has prompted intensive research efforts into glucose\u2010based radiotracers for PET and SPECT imaging. These achievements are also reviewed, along with the use of glycopeptides for nuclear molecular imaging. 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